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食品安全检测中脱氧核酶生物传感技术研究进展

作  者:
邵芙蓉;赵尊全;白家磊;曹高芳;高志贤
单  位:
军事科学院军事医学研究院环境医学与作业医学研究所;滨州医学院公共卫生与管理学院
关键词:
脱氧核酶;生物传感;食品安全;检测技术;生物传感器
摘  要:
脱氧核酶(deoxyribozymes,DNAzymes)是一类具有催化活性的人造脱氧核糖核酸(DNA),因其在生物传感领域存在巨大潜力而受到广泛关注。这些功能性寡核苷酸不仅可以作为特异性的分子识别元件,还能直接通过本身的酶催化活性报告或者传递信号。近年来,基于DNAzyme的生物传感技术在食品安全领域的研究和应用得到了迅速发展。本文重点关注了近3年来的文献资料,综述了DNAzyme的催化机制和生物传感策略以及它们在食品安全快速检测中的研究进展,并讨论了未来该生物传感技术在食品样品分析检测中可能的发展趋势和方向。
作  者:
SHAO Furong;ZHAO Zunquan;BAI Jialei;CAO Gaofang;GAO Zhixian;School of Public Health and Management, Binzhou Medical College;Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental Medicine and Operational Medicine, Academy of Military Medicine, Academy of Military Sciences;
关键词:
deoxyribozymes;;biosensing;;food safety;;detection technology;;biosensor
摘  要:
Deoxyribozymes(DNAzymes),?a?class?of?artificial?DNA?sequences?with?catalytic?activities,?have?attracted?much?attention?due?to?their?great?potential?in?biosensing.?These?functional?oligonucleotides?can?not?only?serve?as?specific?molecular?recognition elements, but also report or transduce signals directly through their catalytic activity. In recent years, DNAzymebased?biosensing?technology?is?developing?rapidly?in?the?field?of?food?safety.?This?article?provides?an?overview?of?catalytic?mechanism and biosensing strategy of DNAzymes, and reviews their progress in rapid detection for food safety, with a focus on?the?scientific?literature?in?the?past?three?years.?Finally,?we?discuss?possible?future?trends?and?directions?of?this?biosensing?technology in the analysis and detection of food samples.

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