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当前位置: 首页 > 文章 > 姜黄素对草鱼急性肝损伤的保护作用研究 湖北农业科学 2016,55 (6) 1514-1517
Position: Home > Articles > The Protective Effect of Curcumin in Acute Hepatic Injuried Ctenopharyngodon idellus Hubei Agricultural Sciences 2016,55 (6) 1514-1517

姜黄素对草鱼急性肝损伤的保护作用研究

作  者：
喻运珍;余少梅;熊文静;张生元;徐志强;郑翠华;周汝珍
单  位：
武汉市水产科学研究所;黄冈市水产科学研究所;华中农业大学水产学院;中博水产生物技术有限公司
关键词：
草鱼(Ctenopharyngodon idellus);CCl_4;姜黄素;肝损伤
摘  要：
以CCl_4诱导的草鱼(Ctenopharyngodon idellus)急性肝损伤模型为基础,考察姜黄素对肝脏组织的保护作用。对草鱼腹腔注射不同剂量CCl_4-橄榄油后,分别于不同时间点测定血清中谷丙转氨酶(GPT)、谷草转氨酶(GOT)活性,确定CCl_4-橄榄油最佳注射剂量和作用时间;以建立的草鱼急性肝损伤模型为基础,采用不同浓度姜黄素(5、25、75、150、300 mg/kg)进行灌胃给药,观察草鱼血清和肝脏组织中相关生化指标变化情况。结果表明,用15%的CCl_4-橄榄油腹腔注射(剂量为0.1 m L/10 g鱼体重)24 h后,使草鱼血清中GPT、GOT水平升高(P<0.05);同时,150 mg/kg姜黄素能显著(P<0.05)抑制血清中GOT和GPT水平的升高。姜黄素对CCl_4诱导的草鱼肝组织损伤具有保护作用。
译  名：
The Protective Effect of Curcumin in Acute Hepatic Injuried Ctenopharyngodon idellus
作  者：
YU Yun-zhen;YU Shao-mei;XIONG Wen-jing;ZHANG Sheng-yuan;XU Zhi-qiang;ZHENG Cui-hua;ZHOU Ru-zhen;Wuhan Institute of Fishery;Wuhan Chopper Fishery Bio-tech Co.,Ltd.;College of Fisheries,Huazhong Agricultural University;Huanggang Institute of Fishery;
关键词：
Ctenopharyngodon idellus;;carbon tetrachloride;;curcumin;;hepatotoxicity
摘  要：
The present study aimed to develop a vivo model of acute hepatotoxicity using carbon tetrachloride(CCl_4) as hepatotoxicant and to evaluate the antioxidant effects of Curcumin against CCl_4 induced hepatotoxicity in Ctenopharyngodon idellus.The Grass carp model of acute hepatic injury was induced by intraperitoneal injection of CCl_4.To define the most optimal CCl_4 action concentration and time, the activity of the serum glutamate oxalate transaminase(GOT),glutamate pyruvate transaminase(GPT) were detected at different time and doses. The Grass carp was gavaged the agentia containing Curcumin at different content(5,25,75,150,300 mg / kg)to CCl_4 intoxication, and the changes in hepatic function markers in serum were analyzed to evaluate the antioxidant effects of Curcumin on the hepatopancrease. Results showed that the serum level of GOT and GPT activities were found to be significantly elevated in the group injected with 15.00% CCl_4 in olive oil at a volume of 0.1m L / 10 g of body weight for 24 h; Meanwhile, Curcumin at the content of 150 mg / kg led to significant reduce in the activities of GPT and GOT.The findings proved the hepatoprotective action of Curcuma in fish.

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