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当前位置: 首页 > 文章 > 杨梅叶原飞燕草素对胰脂肪酶和磷脂酶A1的影响 食品科学 2018 (11) 165-170
Position: Home > Articles > Effect of Prodelphinidins from Chinese Bayberry Leaves on Pancreatic Lipase and Phospholipase A1 FOOD SCIENCE 2018 (11) 165-170

杨梅叶原飞燕草素对胰脂肪酶和磷脂酶A1的影响

作  者：
周晓舟;陈士国;叶兴乾
单  位：
浙江大学生物系统工程与食品科学学院
关键词：
杨梅叶;原飞燕草素;胰脂肪酶;磷脂酶A1;减肥
摘  要：
比较了奥利司他(Orlistat)以及不同加工程度的杨梅叶原飞燕草素提取物(杨梅叶粉末、杨梅叶含糖提取物和杨梅叶去糖提取物)对胰脂肪酶和磷脂酶A1在体外以及SD大鼠小肠内的活性抑制能力。结果表明:Orlistat对体外和大鼠小肠内的胰脂肪酶的活性抑制率均为最高,分别为99.0%和96.5%,排在第二的去糖提取物分别为90.9%和91.4%;Orlistat对体外和大鼠小肠内的磷脂酶A1的活性抑制率也均为最高,分别为97.1%和97.2%,排在第二的去糖提取物分别为96.7%和87.7%。检测了去糖提取物的半抑制浓度,对于胰脂肪酶和磷脂酶A1分别为0.01 mg/m L和0.06 mg/m L,分析其对胰脂肪酶的抑制类别为竞争性抑制+反竞争性抑制,对磷脂酶A1的抑制类别为竞争性抑制,杨梅叶原飞草素是一种潜在的高效、可控的新型减肥产品。
译  名：
Effect of Prodelphinidins from Chinese Bayberry Leaves on Pancreatic Lipase and Phospholipase A1
作  者：
ZHOU Xiaozhou;CHEN Shiguo;YE Xingqian;School of Biosystems Engineering and Food Science, Zhejiang University;
关键词：
Chinese bayberry leaves;;prodelphinidins;;pancreatic lipase;;phospholipase A1;;anti-obesity
摘  要：
The effect of prodelphinidin extracts from Chinese bayberry leaves at different processing stages(leaf powder, non-desugarized prodelphinidin extract, and desugarized prodelphinidin extract) on pancreatic lipase and phospholipase A1 was evaluated in vitro and in the small intestine of SD rats in comparison with Orlistat. The results indicated that Orlistat had the highest inhibition percentage against pancreatic lipase in vitro and in the small intestine of SD rats, which were 99.0%and 96.5%, respectively, followed by the purified prodelphinidins(90.9% and 91.4%, respectively). Also, Orlistat had the highest inhibition percentage against phospholipase A1 in vitro and in the small intestine of SD rats, which were 97.1%and 97.2%, respectively, followed by the purified prodelphinidins(96.7% and 87.7%, respectively). The half maximal inhibitory concentration of the purified prodelphinidins against pancreatic lipase and phospholipase A1 were 0.01 and 0.06 mg/m L, respectively. The type of inhibition was competitive + uncompetitive for pancreatic lipase and was competitive for phospholipase A1. The purified prodelphinidins from Chinese bayberry leaves are potentially an efficient and controllable anti-obesity agent.

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