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当前位置: 首页 > 文章 > 不同干燥方法对乳源血管紧张素转化酶抑制肽活性的影响 食品科学 2016,37 (19) 204-210
Position: Home > Articles > Effect of Different Drying Methods on Angiotensin Converting Enzyme Inhibitory Activity of Peptides from Bovine Casein Hydrolysate FOOD SCIENCE 2016,37 (19) 204-210

不同干燥方法对乳源血管紧张素转化酶抑制肽活性的影响

作  者：
胡志和;赵勇;夏磊;李艳军;薛璐;孙振刚;武文起;冯永强
单  位：
天津海河乳业有限公司;天津商业大学生物技术与食品科学学院
关键词：
酪蛋白水解物;血管紧张素转化酶活性抑制肽;真空冷冻干燥;喷雾干燥;流化床干燥
摘  要：
用不同的干燥方法干燥富含血管紧张素转化酶(angiotensin converting enzyme,ACE)抑制肽的酪蛋白水解物,研究对ACE活性抑制的影响。在研究过程中,采用喷雾干燥法、流化床干燥法和真空冷冻干燥法干燥富含ACE抑制肽的酪蛋白水解产物,以干燥产物的水分含量低于5%为指标,确定干燥条件,以干燥产物的ACE活性半数抑制浓度(half inhibitory concentration,IC50)值,优化干燥条件。并通过动物实验,评价不同干燥方法所得产物的降血压效果。结果显示,采用喷雾干燥法干燥水解产物优化条件为:进风温度190℃、出风温度75℃、进料量44 m L/min,其干燥产物的ACE活性抑制的IC50值为0.442 mg/m L;流化床干燥水解物的条件为:进风温度65℃、进料量180 m L、悬浮介质添加量30 g,其干燥产物ACE活性抑制的IC50值为0.294 mg/m L;真空冷冻干燥产物的ACE活性抑制的IC50值为0.275 mg/m L。动物实验结果显示,采用真空冷冻干燥方法所得干燥产物,最有利于ACE抑制肽活性的保留,其次是流化床干燥,而喷雾干燥产物的活性损失最大。因此,在富含ACE抑制肽水解产物干燥时,采用冷冻干燥方法较好。
译  名：
Effect of Different Drying Methods on Angiotensin Converting Enzyme Inhibitory Activity of Peptides from Bovine Casein Hydrolysate
作  者：
HU Zhihe;ZHAO Yong;XIA Lei;LI Yanjun;XUE Lu;SUN Zhengang;WU Wenqi;FENG Yongqiang;College of Biotechnology and Food Science,Tianjin University of Commerce;Tianjin Key Laboratory of Food and Biotechnology;Tianjin Haihe Dairy Co.Ltd.;
关键词：
casein hydrolysate;;angiotensin converting enzyme(ACE) activity inhibitory peptides;;vacuum freeze drying;;spray drying;;fluid bed drying
摘  要：
The objective of this paper was to explore the effect of different drying methods i.e.,spray drying,fluid bed drying and vacuum freeze drying on the angiotensin converting enzyme(ACE) inhibitory activity of peptides from bovine casein hydrolysate.The operating parameters were optimized to obtain both a moisture content lower than 5% and reduced half inhibitory concentration(IC50) for ACE inhibition of dried product.The antihypertensive efficiency of the dried products obtained by different drying methods was evaluated by animal tests.The results showed that the spray drying conditions were optimized as 190 ℃,75 ℃ and 44 m L/min for air inlet and air outlet temperatures and feeding rate,respectively.The IC_(50) for ACE inhibition of the dried product obtained under these conditions was 0.442 mg/m L.The optimal fluid bed drying conditions were established as 65 ℃,180 m L and 30 g for air inlet temperature,loading amount and suspending medium amount,respectively,which gave a dried product with an IC_(50) of 0.294 mg/m L for ACE inhibition.The IC_(50) for ACE inhibition of the dried product obtained by vacuum freeze drying was 0.275 mg/m L.The results of animal tests showed that upon oral administration of the three different dried products at the same dose,the anti-hypertension activity of dried product was best maintained by by vacuum freeze drying,followed by fluid bed drying,and spray drying caused the maximum loss of anti-hypertension activity.Therefore,vacuum freeze drying is a better drying method for casein hydrolysate rich in ACE inhibitory peptides.

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