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Position: Home > Articles > Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats FOOD SCIENCE 2010,31 (19) 363-366

摄入反式脂肪酸对大鼠脂质代谢的影响

作  者:
张佳;李静;邓泽元;曹君;刘蓉;范亚苇;胡蒋宁
单  位:
南昌大学食品科学与技术国家重点实验室
关键词:
反式脂肪酸;胆固醇代谢;C反应蛋白;脂酶
摘  要:
人群跟踪调查表明,反式脂肪酸(trans fatty acids,TFA)增加冠心病危险及死亡率,可能主要通过影响血脂和炎症反应引起某些慢性疾病。实验在脂肪供能33%(目前中国居民膳食供能比)的情况下,通过90d的大鼠饲养实验探讨以TFA为主的脂肪摄入对大鼠体内脂质代谢的影响。结果表明:与基础饲料对比,以TFA为主的脂肪摄入显著升高大鼠血液甘油三酯(TG)含量,显著降低大鼠高密度脂蛋白胆固醇(HDL-C)含量,显著降低血浆肝素前脂蛋白脂酶(LPL)和肝脂酶(HL)的活力,显示TFA可能改变大鼠脂肪酸代谢,引起甘油三酯代谢异常;TFA同时显著降低大鼠血液血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)含量,且对C反应蛋白(CRP)没有影响,显著升高HDL-C/LDL-C,表明以TFA为主的脂肪摄入可能并不引起大鼠胆固醇代谢异常,这可能是由于除基础饲料外,植物油的摄入没有引入外源胆固醇,且大鼠本身缺乏胆固醇转移蛋白(CETP)。
译  名:
Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats
作  者:
ZHANG Jia1,LI Jing1,,DENG Ze-yuan1,2,CAO Jun1,LIU Rong1,FAN Ya-wei1,HU Jiang-ning1 (1. State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang 330047,China; 2. Institute for Advanced Study of Nanchang University,Nanchang 330047,China)
关键词:
Trans fatty acids;cholesterol metabolism;C-reactive protein;lipase
摘  要:
Epidemiological studies have demonstrated that trans-fatty acid (TFA) intake from diet increase the risk of some chronic diseases through blood lipid metabolism and inflammation pathway. Under the condition of oil added TFA with cholesterol-free (0% cholesterol) and 33% energy supplement from fat,the effect of TFA on lipid metabolism of rats was observed during 90 d feeding. The experimental diet with TFA significantly increased TG,lowered HDL-C,LPL and HL activity,suggesting that TFA could change fatty acid profile to induce the abnormity of TG metabolism. Meanwhile,TFA significantly depressed TC and LDL-C and improved HDL-C/LDL-C ratio,but did not exhibit effect on C-reactive protein (CRP) due to having no effect on the abnormity of cholesterol metabolism.

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