当前位置: 首页 > 文章 > IAP抑制剂增强TRAIL诱导肿瘤细胞凋亡的研究进展 河北北方学院学报(自然科学版) 2019 (6) 57-60
Position: Home > Articles > IAP抑制剂增强TRAIL诱导肿瘤细胞凋亡的研究进展 Journal of Hebei North University(Natural Science Edition) 2019 (6) 57-60

IAP抑制剂增强TRAIL诱导肿瘤细胞凋亡的研究进展

作  者:
郝金莉;罗保斌;魏燕妮;李慧萍
单  位:
北京中医药大学东直门医院;潍坊护理职业学院
关键词:
细胞凋亡;肿瘤坏死因子相关凋亡诱导配体;凋亡抑制蛋白;IAP抑制剂
摘  要:
肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-related apoptosis inducing ligand,TRAIL)可高效、特异地诱导肿瘤细胞凋亡,但某些肿瘤细胞对TRAIL介导的细胞凋亡并不敏感.凋亡抑制蛋白(inhibitor of apoptosis proteins,IAPs)抑制剂与TRAIL联合应用能够显著增强TRAIL介导的肿瘤细胞凋亡.综述了IAP抑制剂对TRAIL的协同增效作用及可能的机制.
作  者:
HAO Jin-li;LUO Bao-bin;WEI Yan-ni;LI Hui-ping;Clinical Laboratory,Dongzhimen Hospital,Beijing University of Chinese Medicine;Wei Fang Nursing Vocational College;
单  位:
HAO Jin-li%LUO Bao-bin%WEI Yan-ni%LI Hui-ping%Clinical Laboratory,Dongzhimen Hospital,Beijing University of Chinese Medicine%Wei Fang Nursing Vocational College
关键词:
cell apoptosis;;tumor necrosis factor related apoptosis inducing ligand;;inhibitor of apoptosis proteins;;IAP inhibitor
摘  要:
Tumor necrosis factor related apoptosis inducing ligand(TRAIL)can efficiently and specifically induce apoptosis of cancer cells,but some cancer cells are not sensitive to TRAIL-mediated apoptosis.Combination of inhibitor of apoptosis proteins(IAPs)inhibitors and TRAIL can significantly enhance TRAIL-mediated apoptosis of cancer cells.Synergistic effect of IAP inhibitors on TRAIL and its possible mechanism were reviewed.

相似文章

计量
文章访问数: 4
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊