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当前位置: 首页 > 文章 > 响应面法优化辣椒碱β-环糊精包合物制备工艺 湖北农业科学 2016,55 (7) 1808-1812
Position: Home > Articles > Optimization of Preparation Conditions for Capsaicin-β-cyclodextrin Inclusion Complex by Response Surface Methodology Hubei Agricultural Sciences 2016,55 (7) 1808-1812

响应面法优化辣椒碱β-环糊精包合物制备工艺

作  者：
王华;王莹;王翼;詹长娟;徐伟;乔慧
单  位：
南京理工大学泰州科技学院化工学院;江苏农牧科技职业学院动物药学院
关键词：
辣椒碱;β-环糊精;包合物;响应面法
摘  要：
利用饱和水溶液法制备辣椒碱β-环糊精包合物,以包合率和包合物产率为评价指标,通过对包合温度、包合时间及配料比的考察,以响应面法优选最佳工艺条件。结果表明,辣椒碱β-环糊精包合物的最佳包合条件为包合温度50℃,包合时间为3 h,配料比为1∶1(摩尔比),此时包合物平均产率为53.97%,平均包合率为52.51%。采用响应面法可优化辣椒碱β-环糊精包合物的制备工艺,为辣椒碱药物制剂的研发提供借鉴。
译  名：
Optimization of Preparation Conditions for Capsaicin-β-cyclodextrin Inclusion Complex by Response Surface Methodology
作  者：
WANG Hua;WANG Ying;WANG Yi;ZHAN Chang-juan;XU Wei;QIAO Hui;Department of Chemistry, Nanjing University of Science and Technology Taizhou Institute;Department of Pharmacy, Jiangsu Agri-animal Husbandry Vocational College;
关键词：
capsaicin;;β-cyclodextrin;;inclusion complex;;response surface methodology
摘  要：
The inclusion complex was prepared by saturated solution method with inclusion ratio and yield of capsaicin- β-cyclodextrin inclusion complex as indexes, influence of inclusion temperature, inclusion time,and ratio of capsaicin-β-cyclodextrin to inclusion process were investigated by response surface method. Optimum inclusion technology of capsaicin- β-cyclodextrin inclusion complex were as follows:nclusion temperature of 50 ℃,inclusion time of 3 h,ratio of capsaicin-β-cyclodextrin of1∶1. Under the optimized conditions, the yield of capsaicin-β-cyclodextrin inclusion complex was 53.97%,and the inclusion ratio was 52.51%. Using response surface methodology to optimize preparation of capsaicin- β-cyclodextrin inclusion complex had good prediction, and the optimized preparation could be helpful for developing capsaicin agent.

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