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当前位置: 首页 > 文章 > pH响应两亲性壳聚糖衍生物纳米胶束制备、表征及对维生素D_3的体外释放研究 食品工业科技 2014,35 (10) 125-128+133
Position: Home > Articles > pH-responsive amphiphilic chitosan derivative-based nanomicelles:Preparation,characterization and in vitro release of Vitamin D_3 Science and Technology of Food Industry 2014,35 (10) 125-128+133

pH响应两亲性壳聚糖衍生物纳米胶束制备、表征及对维生素D_3的体外释放研究

作  者：
黎文建;彭海龙;熊华;宁方建;张建飞
单  位：
南昌大学食品科学与技术国家重点实验室;南昌大学化学工程系
关键词：
羧甲基壳聚糖;pH响应性;胶束;维生素D3;体外释放
摘  要：
以羧甲基壳聚糖、N,N-二甲基十六烷基叔胺以及丙烯酸为原料合成了一种新型的pH响应性两亲性纳米材料,利用FT-IR对其结构进行了表征。该纳米材料在水溶液中能够自发形成具有壳-核结构的纳米胶束,临界胶束浓度为95mg/L,不同pH条件下粒径分布有较大差异,表面Zeta电位均为正。以维生素D3为模型分子,测得其对VD3的包封率达到57.3%,同时考察了该纳米胶束包裹VD3在不同pH条件下的释放行为,结果显示在人工模拟胃液(SGF)中累积释放量最低(42.1%),人工模拟肠液(SIF)中最高(69.2%)。该纳米胶束的pH响应性行为表明其适宜作为VD3以及其他食品活性成分的潜在纳米生物活性载体。
译  名：
pH-responsive amphiphilic chitosan derivative-based nanomicelles:Preparation,characterization and in vitro release of Vitamin D_3
作  者：
LI Wen-jian;PENG Hai-long;XIONG Hua;NING Fang-jian;ZHANG Jian-fei;State Key Laboratory of Food Science and Technology,Nanchang University;Department of Chemical Engineering,Nanchang University;
关键词：
carboxymethyl chitosan;;pH-responsive;;micelle;;Vitamin D3;;in vitro release
摘  要：
A novel amphiphilic and pH-responsive nanomaterial was synthesized using carboxymethyl chitosan, N,N-dimethylhexadecylamine and acrylic acid. The structure property and critical micelle concentration of the nanomaterial was characterized. The material has the capability of forming core-shell micelles in aqueous solution with critical micelle concentration of 95mg/L. The micelles exhibited different size in diverse pH conditions,and the Zeta potential were all positive charged. Vitamin D3was used as a model molecule,and the results indicated that the solubility of VD3was improved with higher encapsulation efficiency(EE,57.3%). The in vitro release of VD3from the micelle in different pH solution indicated that the VD3-loaded micelle has the highest accumulative release(69.2%) in simulated intestinal fluid(SIF),while the lowest(42.1%) in simulated gastric fluid(SGF). This novel core-shell micelle might be a potential biological carrier for VD3or other bioactive food agents.

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