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当前位置: 首页 > 文章 > 3种黄酮对脂肪肝细胞氧化应激的影响 食品科学 2011,32 (17) 344-348
Position: Home > Articles > Effect of Foodborne Flavonoids on Oxidative Stress in HepG2 Cells FOOD SCIENCE 2011,32 (17) 344-348

3种黄酮对脂肪肝细胞氧化应激的影响

作  者：
谢丽阳;张迪;吴薇;籍保平;赵磊;苏春元
单  位：
中国农业大学食品科学与营养工程学院;中国农业大学工学院;北京工商大学食品添加剂与配料北京高校工程研究中心
关键词：
黄酮;HepG2细胞;活性氧基团;脂肪肝
摘  要：
目的:评价表没食子儿茶素没食子酸酯(EGCG)、表儿茶素、柚皮素3种食源性黄酮对降低脂肪肝细胞模型中氧化应激水平的作用。方法:采用油酸诱导的HepG2细胞建立脂肪肝模型,根据细胞存活率、乳酸脱氢酶(LDH)释放量和活性氧产生量反映细胞损伤程度及氧化应激状态,通过黄酮物质处理后的脂肪肝细胞模型活性氧减少量评价其缓解脂肪肝氧化应激状态的功效。结果:EGCG的抗氧化能力优于表儿茶素,两种物质的抗氧化能力随浓度增加而增强,呈量效关系。柚皮素的抗氧化作用最弱,100μmol/L柚皮素具有促氧化作用。
译  名：
Effect of Foodborne Flavonoids on Oxidative Stress in HepG2 Cells
作  者：
XIE Li-yang1,ZHANG Di1,WU Wei2,JI Bao-ping1,ZHAO Lei3,SU Chun-yuan1(1.College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China;2.College of Engineering,China Agricultural University,Beijing 100083,China;3.Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,Beijing Technology and Business University,Beijing 100048,China)
关键词：
flavonoids;HepG2;ROS;fatty liver
摘  要：
Objective: To evaluate the effects of three foodborne flavonoids including(-)-epicatechin,naringenin and(-)-epigallocatechin gallate(EGCG) on reducing oxidative stress in HepG2 cells.Methods: Oleic acid(OA) was used to induce a fatty liver model in HepG2 cells.Cell injury and oxidative stress in HepG2 cells were evaluated by measuring cell viability,MDA content and ROS generation.The efficacies of three foodborne flavonoids in relieving oxidative stress in HepG2 cells were assessed based on ROS reduction after treatment with each flavonoid.Results: EGCG had better antioxidant effect than(-)-epicatechin and their antioxidant effects were both increased in a dose-dependent fashion.Naringenin revealed the weakest antioxidant effect and was an oxidation promoter at the concentration of 100μmol/L.

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