中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 黄精水煎剂对β-淀粉样蛋白诱导的大鼠学习记忆能力下降的保护作用研究 安徽农业大学学报 2013,40 (1) 101-105
Position: Home > Articles > Protective effects of Polygonatum cyrtonema decoction on beta-amyloid peptide-induced learning and memory decline in rats Journal of Anhui Agricultural University 2013,40 (1) 101-105

黄精水煎剂对β-淀粉样蛋白诱导的大鼠学习记忆能力下降的保护作用研究

作  者：
王涛涛;程娟;姚余有
单  位：
安徽医科大学公共卫生学院
关键词：
黄精;阿尔茨海默病;学习/记忆;p-tau-thr231
摘  要：
本研究旨在探讨黄精水煎剂(PCD)对β-淀粉样蛋白(Aβ)致阿尔茨海默病(AD)模型大鼠的保护作用及可能机制。通过Aβ25-35微量注射至大鼠双侧海马CA1区建立AD模型,同时用PCD干预,研究PCD对AD模型大鼠学习记忆能力、海马组织损伤和CA1区神经元中过度磷酸化tau蛋白(p-tau)表达的影响。结果表明,PCD可明显缩短模型大鼠逃避潜伏期,对模型大鼠学习记忆能力损伤有保护作用;能改善大鼠海马神经元损伤,减少CA1区在thr231位点tau蛋白的过度磷酸化。这些结果提示,PCD对学习记忆能力有显著的保护作用,这可能与其减少海马内p-tau-thr231水平和消除组织氧化逆境有关。
译  名：
Protective effects of Polygonatum cyrtonema decoction on beta-amyloid peptide-induced learning and memory decline in rats
作  者：
WANG Tao-tao CHEN Juan,YAO Yu-you(School of Public Health,Anhui Medical University,Hefei 230032)
关键词：
polygonatum;Alzheimer's disease;learning and memory;phospho-tau-thr231
摘  要：
In order to investigate the protective effects and underlying mechanisms of Polygonatum cyr-tonema decoction(PCD) on amyloid β-peptide(Aβ)-induced Alzheimer's disease(AD) rats,a AD model was es-tablished by injecting Aβ25-35 into the CA1 field of hippocampus,and PCD was simultaneously administered in-tragastrically to the rats.The learning and memory ability,the histopathologic changes and the expression of phospho-tau protein in CA1 field of hippocampus were evaluated in all the rats.The results showed that PCD ob-viously shorten escape latency of model rats,improve histopathologic changes and reduce the excessive expres-sion of p-tau protein on the site of thr231 in CA1 field of hippocampus in model rats.These results suggested that PCD has protective effects on Aβ25-35-induced learning and memory decline in rats,which is likely to be related with its function of reducing the excessive expression of p-tau protein on the site of thr231 and eliminating oxida-tive stress in tissue.

相似文章

导出引用
计量
文章访问数: 6
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46