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莲房原花青素对小鼠S_(180)肉瘤及其免疫功能影响的研究

作  者:
张海晖;段玉清;邓乾春;杨尔宁;谢笔钧
单  位:
华中农业大学食品科技学院天然产物化学研究室;江苏大学生物与环境工程学院
关键词:
莲房原花青素;免疫;抑制作用;S180肉瘤
摘  要:
目的:探讨莲房原花青素(LSPC)对S180肉瘤小鼠及免疫功能的影响。方法:采用称重方法来讨论LSPC对小鼠S180肉瘤的抑制作用;采用小鼠碳廓清单核巨噬细胞吞噬功能测定法、迟发型超敏反应及血清溶血素测定方法,研究LSPC对荷S180肉瘤小鼠免疫功能的影响;结果:LSPC可抑制小鼠S180肉瘤生长、提高免疫器官的增长指数;能显著增强荷瘤小鼠巨噬细胞的吞噬功能、DNFB所致迟发型超敏反应以及抗体生成的能力。结论:初步证明LSPC对小鼠S180肉瘤的抑制作用与其增强荷瘤小鼠免疫功能有关。
译  名:
Effect of LSPC on S_(180) Sarcoma and Immune Function in Mice
作  者:
ZHANG Hai-hui1,DUAN Yu-qing1,2,DENG Qian-chun2,YANG Er-ning2,XIE Bi-jun2 (1.School of Biological and Environmental Engineering, Jiangsu University,Zhenjiang 212013,China; 2.Natural Product Chemistry Research Laboratory, Food Science Department of Huazhong Agricultural, Wuhan 430070,China)
关键词:
Lotus seedpod procyanidins(LSPC);immune;inhibitory;S180 sarcoma
摘  要:
Objective: To discuss the effects of proanthocyanidins from Lotus seedpod (LSPC)on S180 sarcoma and the immune function in mice. Methods: The inhibitory function of LSPC to S180 sarcoma was studied by weighing method, and the effect of LSPC on the immune function in mice was studied through determining carbon granule clearance ability, delayed type hypersen- sitivity (DTH) induced by DNFB and hemolysin production level. Results: LSPC could inhibit the growth of S180 sarcoma in mice, increase the growth index of immune organs, significantly enhance the phagocytosis function of peritoneal macrophage (PMΦ), intensify DTH caused by DNFB, and increase production of antibody. Conclusion: It was primarily proved that LSPC could intensify the immune function in S180 sarcoma-bearing mice and inhibit the mice S180 sarcoma.

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