当前位置: 首页 > 文章 > 黄芪总黄酮对小鼠佐剂性关节炎的治疗作用 安徽农业科学 2015 (27) 77-78
Position: Home > Articles > Treatment Effect of Total Flavonoids of Astragalus on Adjuvant Arthritis in Mice Journal of Anhui Agricultural Sciences 2015 (27) 77-78

黄芪总黄酮对小鼠佐剂性关节炎的治疗作用

作  者:
李航;张冲;王莹;钟雪峰;胡立斌;张雪梅
单  位:
延边大学农学院动物医学系
关键词:
黄芪总黄酮;佐剂性关节炎;治疗作用;小鼠
摘  要:
[目的]研究黄芪总黄酮(TFA)对小鼠佐剂性关节炎的影响。[方法]采用弗氏完全佐剂建立小鼠佐剂性关节炎模型,设立空白组、模型组、阳性组及黄芪总黄酮高、中、低剂量组,测定小鼠足趾肿胀度和脾脏指数,通过Griess法测定血清中NO的含量,ELISA法测定血清中IL-1β的含量。[结果]黄芪总黄酮能减轻佐剂关节炎小鼠足趾肿胀度,下调脾脏指数,抑制血清NO和IL-1β的分泌。[结论]该研究表明黄芪总黄酮对佐剂性关节炎小鼠起到很好的治疗作用,为临床上的应用提供了可靠的试验依据。
译  名:
Treatment Effect of Total Flavonoids of Astragalus on Adjuvant Arthritis in Mice
作  者:
LI Hang;ZHANG Chong;WANG Ying;ZHANG Xue-mei;Department of Animal Medicine,Agricultural College of Yanbian University;
关键词:
Total flavonoids of Astragalus;;Adjuvant arthritis;;Treatment effect;;Mice
摘  要:
[Objective] The research aimed to study the effect of TFA on adjuvant arthritis in mice.[Method]The model of adjuvant arthritis was established by Freund's complete adjuvant. The mice were divided into blank group,model group,positive and TFA high,medium and low doses. The degree of toe swelling and spleen index were observed,the content of NO in serum was determined by Griess method and the content of IL-1β in serum was determined by ELISA method. [Result]TFA could reduce toe swelling degree,abate spleen index,inhibit the secretion of NO and IL-1β. [Conclusion]The results suggest that TFA could significantly treat adjuvant arthritis of mice. It provides a reliable experimental basis for application of TFA in clinic.

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