当前位置: 首页 > 文章 > 川楝子正丁醇部位对小白鼠的急性毒性 贵州农业科学 2015 (1) 108-110
Position: Home > Articles > Acute Toxicity for Mice of the N-butyl Alcohol Extraction from Melia toosendan Guizhou Agricultural Sciences 2015 (1) 108-110

川楝子正丁醇部位对小白鼠的急性毒性

作  者:
陈敏;易文燕;俸婷婷;周英
单  位:
贵州省中药民族药创制工程中心;贵州大学中药天然药研发中心;贵州大学药学院;铜仁职业技术学院
关键词:
川楝子;正丁醇部位;急性毒性;半数致死量
摘  要:
为探明川楝子正丁醇部位的急性毒性,通过预试验测定出川楝子正丁醇部位的最小全死量(Dm)和最大全不死量(Dn),然后进行川楝子正丁醇部位对小白鼠的急性毒性试验。结果表明:川楝子乙醇提取物的正丁醇部位对小白鼠单次口服的半数致死量(LD50)为2.757 1g/kg,95%可信限为2.741 9~2.772 3g/kg。死亡小白鼠急性毒性主要表现为安静少动、腹卧昏睡、呼吸急促、连续抽搐。川楝子正丁醇部位毒性较低,符合低毒化合物标准(500~5 000mg/kg)。
译  名:
Acute Toxicity for Mice of the N-butyl Alcohol Extraction from Melia toosendan
作  者:
CHEN Min;YI Wenyan;FENG Tingting;ZHOU Ying;Tongren Polytechnic College;Guizhou Traditional Chinese Medicine and Ethnodrug Engineering Center;The Research and Development Center of Traditional Chinese Medicine Natural Medicine,Guizhou University;School of Pharmaceutical Sciences,Guizhou University;
关键词:
Melia toosendan;;n-butanol fraction;;acute toxicity;;LD50
摘  要:
To evaluate the acute toxicity of the n-butanol fraction from M.toosendan,minimum amount of Dm and the maximum amount of Dn of the n-butanol fraction from M.toosendan was measured by preliminary test.Then design a test to evaluate the acute toxicity for mice.The results showed that the LD50 of n-butanol fraction from M.toosendan on single dose in mice was 2.757 1g/kg,95% confidencelimit was 2.741 9~2.772 3g/kg.The main acute toxicity symptoms and signs of dead mice included negligent action,shortness of breath,continuous convulsions.According to the national standard of acute toxicity test,the n-butanol fraction from M.toosendan belonged to low-toxic compounds.

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