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Position: Home > Articles > Synthesis of N-(α-Naphthyacetyl)-N′-(2-Propionic Acid)-Thoiurea Journal of Anhui Agricultural Sciences 2008,36 (35) 15297+15363

N-(α-萘乙酰基)-N-′(2-丙酸基)-硫脲的合成

作  者:
赵增兵;时蕾
单  位:
青海师范大学化学系;河南师范大学化学与环境科学学院
关键词:
酰基硫脲;α-萘乙酸;DL-α-丙氨酸;合成
摘  要:
研究了从α-萘乙酸出发,用一锅法合成出N-(α-萘乙酰基)-N-′(2-丙酸基)-硫脲。首先,α-萘乙酸与氯化亚砜反应生成α-萘乙酰氯,然后,再加入硫氰酸钾,并在乙腈为溶剂的条件下,合成α-萘乙酰基硫氰酸酯,最后,再与丙氨酸反应,生成目标产物。所得产物结构经IR初步确证。
译  名:
Synthesis of N-(α-Naphthyacetyl)-N′-(2-Propionic Acid)-Thoiurea
作  者:
ZHAO Zeng-bing et al(Department of Chemistry,Qinghai Normal University,Xining,Qinghai 810008)
关键词:
Acylthiourea;α-naphthyacetic acid;DL-α-alanine;Synthesis
摘  要:
tarting from α-naphthylacetic acid,N-(α-naphthalene acetazolamide)-N′-(2-propionyloxy)-thiourea was synthesized by a pot law.Firstly,α-naphthalene acetyl chloride was synthesized by the reaction of α-naphthylacetic acid and the thionyl chloride.Then,the potassium thiocyanate was added.Under the condition of acetonitrile,α-naphthalene acetazolamide thiocyanic ester was synthesized.Finally,after it was reacted with alanine,the target product was generated.The structure of the compound was preliminarily confirmed by IR.

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