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当前位置: 首页 > 文章 > C57BL/6J近交系脱毛小鼠与正常小鼠毛囊形态学观察及AP-1表达的差异 黑龙江畜牧兽医 2017 (21) 16-18+288
Position: Home > Articles > Morphological observation of hair follicle and difference of AP-1 expression in C57BL/6J hair removal and normal mouse Heilongjiang Animal Science and Veterinary Medicine 2017 (21) 16-18+288

C57BL/6J近交系脱毛小鼠与正常小鼠毛囊形态学观察及AP-1表达的差异

作  者：
王丽;王海涛;李树伟
关键词：
C57BL/6J小鼠;脱毛;毛囊;免疫荧光;AP-1
摘  要：
为了观察并分析C57近交系脱毛小鼠与正常小鼠毛囊形态学的差异,以及对背部皮肤毛囊进行AP-1表达的鉴定,并初步分析AP-1在皮肤毛囊表达的意义,试验通过外科解剖法获取C57近交系脱毛小鼠与正常小鼠背部皮肤,制作石蜡切片并进行Sacpic染色,观察C57近交系脱毛小鼠与正常小鼠毛囊形态学的差异,采用冰冻切片免疫荧光染色鉴定AP-1在皮肤毛囊中的表达。结果表明:C57近交系脱毛小鼠毛囊结构不完整,毛囊结构出现中空,毛囊与皮肤组织之间连接松散;激活蛋白AP-1在正常皮肤毛囊中的表达强于脱毛小鼠皮肤中的毛囊。说明C57近交系脱毛小鼠皮肤毛囊结构被破坏,毛囊稀疏,且毛囊细胞中激活蛋白AP-1的表达弱于正常皮肤毛囊。
译  名：
Morphological observation of hair follicle and difference of AP-1 expression in C57BL/6J hair removal and normal mouse
作  者：
WANG Li;WANG Haitao;LI Shuwei;Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin,College of Life Sciences,Tarim University;
单  位：
Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin,College of Life Sciences,Tarim University
关键词：
C57BL/6J mouse;;hair removal;;hair follicle;;immunofluorescence;;AP-1
摘  要：
The aim of the present study was to analyze the morphological differences of hair follicles and AP-1 expression differences and significance of dorsal skin follicles between C57 hair removal mouse and normal mouse. The dorsal skin of C57 hair removal mouse and normal mouse were obtained by surgical anatomy. The skin was then made into paraffin sections and subjected to Sacpic staining. The morphological differences of hair follicles were observed between C57 hair removal mouse and normal mouse. The expression of AP-1 in the skin follicles was identified by immunofluorescence staining. The results showed that the hair follicle structure of C57 hair removal mouse was not complete. The hollow phenomenon occurs in the hair follicle structure,which is loosely linked to the skin tissue. While the expression of AP-1 in the hair removal mouse was weaker than that of normal mouse skin follicles. The results indicated that the hair follicle structure of C57 hair removal mouse was damaged. The hair follicles was sparse and the expression of AP-1 in the hair follicle cells was weaker than that of normal skin follicles.

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