当前位置: 首页 > 文章 > 大鼠及小鼠口服氯溴酸槟榔碱片剂的急性毒性试验 黑龙江畜牧兽医 2012 (11) 114-115
Position: Home > Articles > Acute toxicity test of arecoline hydrobromide tablets for oral.usein mice and rats Heilongjiang Animal Science and Veterinary Medicine 2012 (11) 114-115

大鼠及小鼠口服氯溴酸槟榔碱片剂的急性毒性试验

作  者:
周绪正;张继瑜;李金善;李剑勇;魏小娟;牛建荣;李冰
单  位:
农业部兽用药物创制重点实验室
关键词:
氢溴酸槟榔碱;小鼠;大鼠;口服;急性毒性;arecoline hydrobromide ; mice ; rats; oral use ; acute toxicity
摘  要:
为了研究氢溴酸槟榔碱片剂对小鼠及大鼠的口服急性毒性,试验以小鼠及大鼠为实验动物,经口一次性灌胃给药,统计死亡率,用改良寇氏法计算半数致死量(LD50)并观察毒性作用。结果表明:氢溴酸槟榔碱片剂对小鼠的口服LD50为6545mg/kg,其95%可信区间为5534—7740mg/kg;对大鼠的最大耐受量(LD0)大于10.0g/kg,则其LD5。必大于10.0g/kg。说明氢溴酸槟榔碱片荆属于低毒性的或实际无毒的药物,以20—50mg/kg的剂量应用于临床非常安全。
译  名:
Acute toxicity test of arecoline hydrobromide tablets for oral.usein mice and rats
摘  要:
To study the acute toxicity of arecoline hydrobromide tablets for oral use in mice and rats, the mice and rats was selected and fed the medicine with one -time oral garage, and then the mortality rate of the mice was counted. The toxic effect'was observed and the LD50 were cal- culated by Karber method. The results showed that the LD50 of arecoline hydrobromide tablets in mice was 6 545 mg/kg, and 95% confidence interval of its LD50 was 5 534 to 7 740 mg/kg. The LD0 of arecoline hydrobromide tablets in rats exceed 10.0 g/kg; and the LD50 of arecoline hydrobromide tablets in rats must be greater than 10.0 g/kg. The results indicate that areeline hydrobromide tablets belong to low - toxicity or actual non - toxic medicine, the dose of 20 to 50 mg/kg is very safe in the clinical application. 引用
-->

相似文章

计量
文章访问数: 12
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊