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当前位置: 首页 > 文章 > 小鼠和大鼠口服氢溴酸槟榔碱的急性毒性试验 动物医学进展 2007,28 (9) 34-36
Position: Home > Articles > Acute Toxicity of Arecoline Hydrobromide in Mice and Rat in Taking Orally Progress in Veterinary Medicine 2007,28 (9) 34-36

小鼠和大鼠口服氢溴酸槟榔碱的急性毒性试验

作  者：
周绪正;张继瑜;赵成莹;李金善;张战峰;李剑勇;魏小娟;牛建荣;王玲
单  位：
中国农业科学院兰州畜牧与兽药研究所新兽药工程重点实验室
关键词：
氢溴酸槟榔碱;小鼠;大鼠;口服;急性毒性
摘  要：
研究口服氢溴酸槟榔碱对小鼠和大鼠的急性毒性,为将其研究开发为新药奠定基础,为临床用量的确定提供科学依据。选用昆明种小鼠及SD大鼠,经口灌胃一次给药,统计死亡率,用改良寇氏法计算半数致死量(LD50),并观察毒性作用。结果氢溴酸槟榔碱对小鼠的口服LD50为691.83 mg/kg,95%可信区间为642.92 mg/kg~744.47 mg/kg;对SD大鼠的口服LD50为2 054 mg/kg,95%可信区间为1 908 mg/kg~2 210 mg/kg。表明氢溴酸槟榔碱属于低毒性的药物,按1 mg/kg~5 mg/kg临床应用非常安全。
译  名：
Acute Toxicity of Arecoline Hydrobromide in Mice and Rat in Taking Orally
作  者：
ZHOU Xu-zheng,ZHANG Ji-yu,ZHAO Cheng-ying,LI Jin-shan,ZHAN Zhan-feng,LI Jian-yong,WEI Xiao-juan,NIU Jian-rong,WANG Ling(Key Laboratory of New Animal Medicine Project,Ministry of Agricultrure,Lanzhou Institute of Animal and Veterinary Pharmceutical Sciences,Chinese Academay of Agricultral Sciences,Lanzhou,Gansu,730050,China)
关键词：
Arecoline hydrobromide;mice;rat;taking orally;acute toxicity
摘  要：
The acute oxicity test of Arecoline hydrobromide in mice and rat in taking orally was carried out in order to establish base for further research and development.then provid science foundation for clinical dosage.The toxic effect was observed and the LD50 were calculated by Karber method. The results suggested that LD50 of Arecoline hydrobromide in rat was 2 054 mg/kg,and 95% average incredible range of its LD50 was 1 908 mg/kg~2 210 mg/kg;and LD50 of Arecoline hydrobromide in mice was 691.83 mg/kg,and 95% average incredible range of its LD50 was 642.92 mg/kg~744.47 mg/kg.The results suggested that Arecoline hydrobromide is the drug of low toxicity,1 mg/kg ~5 mg/kg clinical application very safety.

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