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Position: Home > Articles > A new macrolide antibiotic tulathromycin for animals Guangdong Journal of Animal and Veterinary Science 2010,35 (2) 9-12

动物专用大环内酯类新药——泰拉霉素

作  者:
亢继俊;王丽霞;曾振灵
单  位:
华南农业大学兽医学院广东省兽药研制与安全评价重点实验室
关键词:
泰拉霉素;抗菌活性;药动学;药效学;应用
摘  要:
泰拉霉素是动物专用的新型大环内酯类抗生素,国内已批准用于猪呼吸系统疾病的防治。泰拉霉素的药动学特性优良,吸收快,达峰时间短,生物利用度高,在肺中可达到很高的组织浓度,消除半衰期长,药效持久。单次肌注或皮下给药即能提供全程的治疗,在兽医临床具有广阔的应用前景。本文综述了泰拉霉素的理化性质、作用机理、抗菌活性、药动学、药效学、不良反应及残留,为该药在兽医临床的应用提供参考资料。
译  名:
A new macrolide antibiotic tulathromycin for animals
作  者:
Kang Jijun,Wang Lixia,Zeng Zhenling(College of Veterinary Medicine,Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation,South China Agricultural University,Guangzhou 510642,China)
关键词:
Tulathromycin;antibacterialactivity;pharmacokinetics;pharmacodynamics;application
摘  要:
Tulathromycin is a novel macrolide antibiotic for animals which has been approved for use in the prevention and treatment of swine respiratory disease in China.The antibiotic has good pharmacokinetic characteristic.It can be absorbed quickly,reach the Cmax quickly and be eliminated slowly.Moreover,it can maintain a high concentration in animals' lungs and can provide a full-course therapy after a single dose(im or sc).Tulathromycin could be used extensively in veterinary clinic.Physico-chemical property,action mechanism,antibacterial activity,pharmacokinetics,pharmacodynamics,residue and adverse reaction of tulathromycin were talked in this paper.It will provide information for reasonable application of tulathromycin in veterinary clinic.

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