当前位置: 首页 > 文章 > 泰拉霉素在兔体内的药动学预测 广东畜牧兽医科技 2013,38 (5) 32-35
Position: Home > Articles > Prediction of Pharmacokinetics of Tulathromycin in Rabbits Guangdong Journal of Animal and Veterinary Science 2013,38 (5) 32-35

泰拉霉素在兔体内的药动学预测

作  者:
罗显阳
单  位:
郑州市兽药饲料监察所
关键词:
泰拉霉素;药动学;兔;生理模型
摘  要:
在参考泰拉霉素在绵羊体内的生理模型的基础上,构建泰拉霉素在兔体内的血流限速生理模型,来预测泰拉霉素在兔体内的药动学过程,并将预测值和观测值进行比较。结果表明,泰拉霉素在兔体内具有吸收迅速、分布广泛、消除缓慢、组织药物浓度高等特点。
译  名:
Prediction of Pharmacokinetics of Tulathromycin in Rabbits
作  者:
Luo Xianyang;Zhengzhou Inspection Institute of veterinary drug and feed;
关键词:
Tulathromycin;;Pharmacokinetics;;Rabbits;;PBPK model
摘  要:
On the basis of the physiologically based pharmacokinetic model(PBPK model) of tulathromycin in sheep,a flow-limited PBPK model to predict pharmacokinetic behavior of tulathromycin in rabbits was developped.Predicted values were compared with detected ones.The results indicated that tulathromycin was rapidly absorbed,widely distributed,slowly eliminated and with higher tissue concentrations in rabbits.

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