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Position: Home > Articles > The effect of specific antagonist for miniature pigs' combined anaesthetic on β-EP contents in different encephalic regions in rats Chinese Journal of Veterinary Medicine 2013,49 (11) 6-8+12

小型猪特异性麻醉颉颃剂对麻醉大鼠不同脑区β-内啡肽含量的影响

作者：

侯金龙;姜胜;宋旭东;范宏刚;王洪斌

单位：

东北农业大学动物医学学院

关键词：

小型猪特异性麻醉颉颃剂;脑区;β-内啡肽

摘要：

为研究小型猪特异性麻醉颉颃剂对麻醉大鼠不同脑区β-内啡肽(β-EP)含量的影响,应用小型猪特异性麻醉颉颃剂分别于早期(麻醉后10min)、中期(麻醉后30 min)、晚期(麻醉后60min)催醒XFM麻醉下大鼠。断头取脑后,采用ELISA方法检测大脑皮层、海马、丘脑、小脑、脑干内β-内啡肽的含量变化。结果显示,苏醒过程中恢复直线爬行时脑内β-内啡肽含量高于恢复翻正反射即刻,呈现升高趋势;早期试验组海马、脑干,中期催醒试验组海马、丘脑、小脑、脑干内β-EP含量恢复翻正反射时显著低于对照组(P<0.05),由此推断小型猪特异性麻醉颉颃剂可能是通过减少脑中β-EP含量,降低XFM对中枢神经的抑制作用,缩短小型猪苏醒时间,这可能是小型猪特异性麻醉颉颃剂产生催醒作用的机制之一。

译名：

The effect of specific antagonist for miniature pigs' combined anaesthetic on β-EP contents in different encephalic regions in rats

作者：

HOU Jin-long;JIANG Sheng;SONG Xu-dong;FAN Hong-gang;WANG Hong-bin;College of Veterinary Medicine,Northeast Agricultural University;

关键词：

antagonist;;anaesthetic;;encephalic region;;β-EP

摘要：

To study the effect of the specific antagonist for miniature pigs' combined anaesthetic on(S-EP contents in different encephalic regions,96 rats were injected by the specific antagonist for miniature pigs' combined anaesthetic after anesthetizing 10min,30min and 60min separately.The β-EP contents were measured by Enzyme-Linked Immunosorbent Assay(ELISA).The results showed that the β-EP contents in each group were higher at the moment of rectilinear creeping than at the moment of recovering body-right reflex(P <0.05);The β-EP contents in the early experimental groups was lower than in the controls at the moment of recovering body-right reflex in the brain stem and hippocampus regions(P <0.05).The 3-EP contents in the middle experimental groups was also lower than that of controls at the moment of recovering body-right reflex in the brain stem,thalamus,cerebellum and hippocampus regions(P <0.05).It was concluded that the Specific antagonist for miniature pigs' combined anaesthetic took effects on arousing by reducing the β-EP contents.This might be one of the mechanism for the specific antagonist for miniature pigs' combined anaesthetic.

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小型猪特异性麻醉颉颃剂对麻醉大鼠不同脑区β-内啡肽含量的影响

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