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Position: Home > Articles > Hypoxia Inducible Factor-1α and Ascites in Broiler China Poultry 2006,28 (20) 99-101

缺氧诱导因子-1α与肉鸡腹水综合征

作  者:
曾秋凤;陈代文
单  位:
四川农业大学动物营养研究所
关键词:
缺氧诱导因子-1α;肺动脉高压;腹水综合征;肉鸡
摘  要:
缺氧诱导因子-1α(HIF-1α)是机体缺氧信号传导途径中一个关键的转录因子-缺氧诱导因子-1(HIF-1)的一个活性亚基,对人类和哺乳动物肺动脉高压的形成具有极其重要的病理生理作用。文章综述了HIF-1α与哺乳动物肺动脉高压发生发展的关系及其可能的作用机理与途径,对剖析HIF-1α在肉鸡腹水综合征发生发展中的作用机理具有一定的意义。
译  名:
Hypoxia Inducible Factor-1α and Ascites in Broiler
作  者:
Zeng Qiufeng,Chen Daiwen (Institute of Animal Nutrition,Sichuan Agricultural University,Sichuan,Ya′an 625014)
关键词:
hypoxia-inducible factor 1 α;pulmonary hypertension;ascites;broiler
摘  要:
Hypoxia-inducible factor 1 α(HIF-1α)is an active subunit of a key transcription factor in oxygen-sensing pathway-Hypoxia-inducible factor 1.HIF-1α plays key roles in oxygen homeostasis and pulmonary hypertension development.Effects of HIF-1α on pulmonary hypertension in human or mammalian and ascites in broilers,the mechanism of HIF-1α in development of pulmonary hypertension were summarized in this paper.There will be theoretical significance for expounding the mechanism of HIF-1α in development of ascites in broilers.

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