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当前位置: 首页 > 文章 > 响应面分析法优化葫芦素B脂质纳米粒高压均质生产工艺 食品工业科技 2017 (12) 254-257+263
Position: Home > Articles > Optimization of solid lipid nanoparticle of cucurbitacin B by response surface methodology Science and Technology of Food Industry 2017 (12) 254-257+263

响应面分析法优化葫芦素B脂质纳米粒高压均质生产工艺

作  者：
刘钰莹;赵春燕;马越;赵晓燕;张超
单  位：
沈阳农业大学食品学院;北京市农林科学院蔬菜研究中心果蔬农产品保鲜与加工北京市重点实验室农业部华北地区园艺作物生物学与种质创制重点实验室农业部都市农业(北方)重点实验室
关键词：
葫芦素B;脂质纳米粒;响应面法;包封率
摘  要：
以葫芦素B、脂质(单硬脂酸甘油酯)和乳化剂(泊洛沙姆188和大豆卵磷脂等比例混合物)为原料,采用高压均质法制备葫芦素B脂质纳米粒。以单因素实验考察均质压力、脂质含量、乳化剂含量对葫芦素B脂质纳米粒包封率的影响,并采用响应面实验优化葫芦素B脂质纳米粒生产工艺。结果表明:均质压力对葫芦素B脂质纳米粒包封率的影响最大,其次为脂质和乳化剂含量。当压力为74.8 MPa,乳化剂、脂质及葫芦素B三者含量比为12.6∶10.3∶1时,葫芦素B脂质纳米颗粒包封率达到最高值,为92.4%,与理论值仅差1.62%,模型真实可靠。
译  名：
Optimization of solid lipid nanoparticle of cucurbitacin B by response surface methodology
作  者：
LIU Yu-ying;ZHAO Chun-yan;MA Yue;ZHAO Xiao-yan;ZHANG Chao;Beijing Vegetable Research Center,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Fruits and Vegetable Storage and Processig,Key Laboratory of Biology and Genetic Improvement of Horticultural Crops( North China) ,Ministry of Agriculture,Key Laboratory of Ubran Agriculture( North) ,Ministry of Agriculture;College of Food Science,Shenyang Agricultural University;
关键词：
cucurbitacin B;;solid lipid nanoparticles;;response surface methodology;;encapsulation efficiency
摘  要：
The solid lipid nanoparticle of cucurbitacin B was prepared by high pressure homogenization with the lipid of monoglyceride,the emulsifier of mixture of the soybean lecithin and poloxamer 188(1∶1).The parameters of the high pressure homogenization were optimized by response surface methodology with the homogenization pressure,lipid content and emulsifier content as the main factors,and the encapsulation efficiency as the response. The homogenization pressure was the key factor affecting the encapsulation efficiency of cucurbitacin B,followed by the lipid content and emulsifier content. When the homogenization pressure was 74.8 MPa,and the ratio of the lipid-emulsifier-cucurbitacin B was 12.6∶10.3∶1,the encapsulation efficiency of cucurbitacin B reached the maximum of 92.4%. The validation experiment showed that the relative deviation between real and theoretical value was only 1.62%.The regression model was reliable.

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