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Position: Home > Articles > Inhibited Effects and Mechanisms of Cucurbitacin B on Apoptosis of Neonate Rat Hepatocytes Induced by H_2O_2 FOOD SCIENCE 2005,26 (9)

葫芦素B对过氧化氢诱导的大鼠肝细胞凋亡的抑制作用

作  者：
曹淑桂;昌友权;曲红光;郑丽华;魏征人;杨世杰
单  位：
吉林大学基础医学院药理教研室;吉林大学分子酶学工程教育部重点实验室
关键词：
葫芦素B;凋亡;肝细胞
摘  要：
葫芦素B是从甜瓜茎中提取的药用成分,以前的研究成果已经发现,该药具有保肝作用。但是其作用机制还不是很清晰,本实验探讨的是葫芦素B是否通过抑制凋亡信号转导而达到保肝的目的。过氧化氢诱导的乳鼠凋亡模型,然后给与不同剂量三个浓度的葫芦素B(3、10、30mmol/L)。通过流式细胞计量术测量细胞早期凋亡率。与模型组比较,高中剂量组能明显降低肝细胞早期的凋亡率(p<0.05)。上述结果表明葫芦素B能抑制过氧化氢诱导的乳鼠肝细胞的凋亡,从而达到保肝的药理学作用
译  名：
Inhibited Effects and Mechanisms of Cucurbitacin B on Apoptosis of Neonate Rat Hepatocytes Induced by H_2O_2
作  者：
CAO Shu-gui1,CHANG You-quan1,3,*,QU Hong-guang2,ZHENG Li-hua2, WEI Zheng-ren2, YANG Shi-jie2 (1.Key Aboratory of Molecular Enzymology and Engineering of Educational Ministry, Jilin University, Changchun 130023, China;2.Department of the Pharmacological, School of Basic Medical, Jilin University, Changchun 130021, China;3. Department of Biology and Food Engineerning, Jilin Normal Institute of Engi- neering and Technology, Changchun 130052, China)
关键词：
cucurbitacin B; apoptosis;hepatocytes
摘  要：
Cucurbitacin B is a pharmaceutical component extracted from stalk of muskmelon. Previous studies have demonstrated that it can prevent damage of hepatocytes. But this mechanism was not cleared yet. The aim of our work is to study cucurbitacin B protecting effects on hepatocytes associated with inhibiting apoptosis signals transduction. The apoptosis model of neonate rat was constructed by induction of H2O2, and then hepatocytes were treated with cucurbitacin B in three concentrations of various dose(3,10,30mmol/L respectively).Flow cytometry were conducted to investigate early apoptosis ratio. The ratio of early apoptosis cells in high(21.4%) and middle dose groups(36.2%) was decreased significantly compared with model group(68. 3%, p<0.01). The results suggested that cucurbitacin B could inhibit the apoptosis of neonate rat hepatocytes induced by H 2 O 2 .

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