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当前位置: 首页 > 文章 > 盐酸沙拉沙星在蛋鸡体内的组织动力学的研究 黑龙江畜牧兽医 2001,1 (4) 3-4
Position: Home > Articles > Studies on Tissue Pharmcokinetics of Sarafloxacin Hydrochloride in Chicken Heilongjiang Animal Science and Veterinary Medicine 2001,1 (4) 3-4

盐酸沙拉沙星在蛋鸡体内的组织动力学的研究

作  者：
李艳华;佟恒敏;李银生
单  位：
西南农业大学动物养殖学院;东北农业大学动物医学院
关键词：
盐酸沙拉沙星;鸡;组织动力学
摘  要：
为研究盐酸沙拉沙星在蛋鸡体内组织动力学 ,选用成年健康蛋鸡 90只进行试验。按 10mg/kg体重口服给药 ,定期采样 ,测定心、肝、肾脏、肌肉中盐酸沙拉沙星的含量。结果表明 :心脏符合一级吸收三项指数方程 ,理论方程为 :Ch=0 .145 5e-0 .0 2 4 3t+ 2 .484e-0 .54 40 3t- 2 .6 2 9e-0 .8617t;肾脏符合一级吸收三项指数方程 ,理论方程为 :Ck=1.70 3e-0 .12 6t+ 0 .32 83e-0 .2 111t- 2 .0 312e-0 .4 976t;肝脏符合一级吸收二项指数方程 ,理论方程为 :Cl=6 .732 (e-0 .1810 3t-e-0 .110 8t) ;肌肉符合一级吸收二项指数方程 ,理论方程为 :Cm=0 .9188(e0 .1579t-e-0 .2 0 14t)。
译  名：
Studies on Tissue Pharmcokinetics of Sarafloxacin Hydrochloride in Chicken
作  者：
LI Yan-hua 1 ,TONG Heng-min 1 ,LI Yin-sheng 2 (1.College of Vet Med.Northeast Agriculture University,Harbin 150030,China; 2.College of Animal Science.Southwest Agriculture University,Chong qing 400716,China)
关键词：
Sarafloxacin Hydrochloride;chicken;tissue pharmacokinetics ;
摘  要：
healthy chickens were selected to study tissue pharmacokinetics of Sarafloxacin Hydrochloride.The samples were collected and measured after oral administration(10 mg/kg) .The results are as follows: the heart concentration -time data of Sarafloxacin Hydrochloride was best described by a triexponential equation with first order absorption.Its theoretical equation was as follows:C h =0.1455e -0.0243 +2.484 e -0.54403t -2.629e -0.8617t .The kidney concentration-time data of Sarafloxacin Hydrochloride was best described by a triexponential equation with first order absorption.Its the oretical equation was: C k =1.703e -0.126t +0.3283e -0.2111t -2.0312e -0.4976t . The liver concentration -time data of Sarafloxacin Hydrochloride was best described by a triexponential equation with first order absorption. Its theoretical equation was: C k = 6 732(e -0.18103t -e -0.1108t ).The muscle concentration -time data of Sarafloxacin Hydrochloride was best described by a biexponential equation with first order absorption.Its theoretical equation was as follows:C m=0.9188(e 0.1579t -e -0.2014t ).

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