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当前位置: 首页 > 文章 > 市售氯硝柳胺在斑点叉尾组织中的残留消除规律研究 淡水渔业 2013,43 (5) 37-42
Position: Home > Articles > Residue determination and degradation of niclosamide in Ictalarus puctatus tissue Freshwater Fisheries 2013,43 (5) 37-42

市售氯硝柳胺在斑点叉尾组织中的残留消除规律研究

作  者：
索纹纹;刘永涛;艾晓辉;吕思阳;杨秋红;余少梅
单  位：
中国水产科学研究院长江水产研究所
关键词：
氯硝柳胺;斑点叉尾(Ictalurus punctalus);消解;残留
摘  要：
为了研究氯硝柳胺在斑点叉尾(Ictalurus punctalus)组织中的残留消除规律,在静水条件下经安全性试验确定安全浓度后,直接对水族箱泼洒25%氯硝柳胺乙醇胺盐(NES)粉剂后采集斑点叉尾皮肤、肌肉和水样。采用高效液相色谱-质谱联用法(HPLC-ESI/MS/MS)测定样品中氯硝柳胺的浓度,结果表明,静水条件下25%氯硝柳胺乙醇胺对斑点叉尾的安全浓度为0.113 mg/kg;养殖水环境中氯硝柳胺能快速消解,实验第2天即低于1μg/L,并呈无规律性持续较长时间;用药24 h内,氯硝柳胺在鱼体肌肉和鱼皮中具有较强的蓄积能力,但48 h后,其在鱼皮和肌肉中呈现快速消除至较低浓度,但后期消除缓慢,并会持续一定时间;氯硝柳胺(NIC)在斑点叉尾肌肉和鱼皮中的消除半衰期T1/2分别为10.66和9.24 d,显著大于在水体中的消除半衷期。
译  名：
Residue determination and degradation of niclosamide in Ictalarus puctatus tissue
作  者：
SUO Wen-wen;LIU Yong-tao;AI Xiao-hui;LV Si-yang;YANG Qiu-hong;YU Shao-mei;Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences Freshwater Fish Germplasm Quality Supervision and Testing Center,Ministry of Agriculture;Hunan Fisheries Science institute;Hubei Cooperative Inovation Center of Healthy Freshwater Aquaculture;Wuhan Chopper Fishery Bio-Tech Co.Ltd;
关键词：
niclosamide;;Ictalarus puctatus;;degradation dynamics;;residue
摘  要：
Accumulation and elimination of Niclosamide(NIC) in Ictalurus punctatus tissue and water under indoor static water laboratory test were studied.We took the method of splashing 25% Niclosamide ethanolamine salt(NES) under the safe concentration into aquarium after the safety testing and the same sizes of I.punetaus(133.42±26.2) g were exposed to freshwater containing NES under static conditions.The concentrations of NIC in water and tissue(muscle,skin) samples were determined by liquid chromatography tandem mass spectrometric(HPLC-ESI/MS/MS).The results showed that the safe concentration of 25% NES on I.Punetaus was 0.113 mg/L.NIC concentration in water decreased quickly on the first day,then it was lower than 1 μg/L and maintained in a certain period,but the NIC concentration in muscle and skin presented enriched obviously on the first day,then the elimination trends started to level off and maintained a certain concentration fraction in a certain period.The elimination half-life of NIC in muscle and skin were 10.66 and 9.24,respectively,which were significantly higher than that in water.

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