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当前位置: 首页 > 文章 > 市售氯硝柳胺在斑点叉尾(鱼回)组织中的残留消除规律研究 淡水渔业 2013,43 (5) 37-42
Position: Home > Articles > Residue determination and degradation of niclosamide  in Ictalarus puctatus tissue Freshwater Fisheries 2013,43 (5) 37-42

市售氯硝柳胺在斑点叉尾(鱼回)组织中的残留消除规律研究

作  者：
索纹纹;刘永涛;艾晓辉;吕思阳;杨秋红;余少梅
关键词：
氯硝柳胺;斑点叉尾(鱼回)(Ictalurus;punctalus);消解;残留;(鱼回)
摘  要：
为了研究氯硝柳胺在斑点叉尾(鱼回)(Ictalurus punctalus)组织中的残留消除规律,在静水条件下经安全性试验确定安全浓度后,直接对水族箱泼洒25%氯硝柳胺乙醇胺盐(NES)粉剂后采集斑点叉尾(鱼回)皮肤、肌肉和水样.采用高效液相色谱.质谱联用法(HPLC-ESI/MS/MS)测定样品中氯硝柳胺的浓度,结果表明,静水条件下25%氯硝柳胺乙醇胺对斑点叉尾(鱼回)的安全浓度为0.113mg/kg;养殖水环境中氯硝柳胺能快速消解,实验第2天即低于1μg/L,并呈无规律性持续较长时间;用药24h内,氯硝柳胺在鱼体肌肉和鱼皮中具有较强的蓄积能力,但48h后,其在鱼皮和肌肉中呈现快速消除至较低浓度,但后期消除缓慢,并会持续一定时间;氯硝柳胺(NIC)在斑点叉尾(鱼回)肌肉和鱼皮中的消除半衰期T1/2分别为10.66和9.24d,显著大于在水体中的消除半衷期.
译  名：
Residue determination and degradation of niclosamide  in Ictalarus puctatus tissue
关键词：
niclosamide% Ictalarus puctatus% degradation dynamics% residue
摘  要：
Accumulation and elimination of Niclosamide (NIC) in Ictalurus punctatus tissue and water under indoor static water laboratory test were studied. We took the method of splashing 25% Niclosamide ethanolamine salt(NES) under the safe concentration into aquarium after the safety testing and the same sizes of I. punetaus ( 133.42±26. 2) g were exposed to freshwater containing NES under static conditions. The concentrations of NIC in water and tissue (muscle, skin) samples were determined by liquid chromatography tandem mass spectrometric (HPLC-ESI/MS/MS). The results showed that the safe concentration of 25% NES on 1. Punetaus was 0. 113 mg/L. NIC concentration in water decreased quickly on the first day, then it was lower than 1 p~g/L and maintained in a certain period, but the NIC concentration in muscle and skin presented enriched obviously on the first day, then the elimination trends started to level off and maintained a certain concentration fraction in a certain period. The elimination half-life of NIC in muscle and skin were 10. 66 and 9. 24, respectively, which were significantly higher than that in water.

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