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Position: Home > Articles > Studies on Inhibitor Effects and Activator of α-glucosidase in Mulberry Leaves FOOD SCIENCE 2006,27 (2) 108-111

桑叶中α—葡萄糖苷酶活性调节成分的研究

作  者:
马庆一;时国庆;陈春涛;孙佳;陈晓燕
单  位:
郑州轻工业学院食品与生物工程学院
关键词:
α-葡萄糖苷酶抑制剂;多糖;黄酮;糖尿病;桑叶
摘  要:
从桑叶中提取、分离并部分纯化了多糖和黄酮。酶反应动力学研究结果表明,桑叶多糖是良好的α-葡萄糖苷酶竞争性抑制剂,其抑制率约比拜糖平片高8倍多,抑制率随浓度升高而增大,作用时间为5min时抑制效果最好。桑叶黄酮对α-葡萄糖苷酶有激活作用,是潜在的升糖功能因子。在桑叶黄酮加入乳化剂硬脂酸单甘酯,可改善黄酮在水中的分散度,解决了水溶性欠佳的黄酮酶活性调节剂的动力学测定问题。
译  名:
Studies on Inhibitor Effects and Activator of α-glucosidase in Mulberry Leaves
作  者:
MA Qing-yi,SHI Guo-qing,CHEN Chun-tao,SUN Jia,CHEN Xiao-yan (College of Food and Biological Engineering, Zhengzhou Institute of Light Industry, Zhengzhou 450002, China)
关键词:
inhibitor of α-glucosidase;polysaccharide;flavones;diabetes;mulberry leaves
摘  要:
Polysaccharide and flavones were extracted, isolated, and partially purified from mulberry leaves. The results from studies by using enzymatic kinetics showed that, mulberry leave polysaccharide was an excellent competitive inhibitor of α- glucosidase for glucose releasing. Its inhibitory rate increased with increasing concentration. The optimum acting time for polysaccharide inhibition was 5min. Mulberry leave flavone was found as an activator of α-glucosidase, a potential functional factor for increasing blood sugar. Glycerol monostearicate, as an emulsifier, was introduced into the enzymatic reaction solvent system to enhance the homogeneity of flavones in water.

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