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当前位置: 首页 > 文章 > 中国沿海两例食用织纹螺中毒事件中织纹螺体内毒素分析 中国水产科学 2007,14 (5) 801-806
Position: Home > Articles > Analysis of toxins in snails responsible for two poisoning incidents in China Journal of Fishery Sciences of China 2007,14 (5) 801-806

中国沿海两例食用织纹螺中毒事件中织纹螺体内毒素分析

作  者：
于仁成;周名江;李爱峰;张清春;王云峰;李钧;颜天;Michael Quilliam;Bernd Luckas
单  位：
Institute of Nutrition;中国海洋大学海洋环境与生态教育部重点实验室;中国科学院海洋研究所海洋生态与环境科学重点实验室;Canada;B3H3Z1;Institute of Marine Bioscience National Research Council of Canada;Jena;Halifax;Germany;Friedrich Schiller-University of Jena
关键词：
织纹螺;河豚毒素;麻痹性贝毒毒素;亲水性相互作用色谱;液相色谱-质谱联用分析
摘  要：
近年来,因食用织纹螺(Nassariusspp.)导致的中毒事件在中国沿海屡有发生。由于中毒患者的症状与麻痹性贝毒中毒症状相似,因此,许多中毒事件被归咎于麻痹性贝毒,认为织纹螺中的毒素与邻近海域的有毒赤潮有关,但也有研究发现螺体内存在河豚毒素。对此,本研究应用亲水性相互作用色谱柱建立了河豚毒素的液相色谱-质谱联用分析方法,对造成2002年和2003年两次中毒事件的织纹螺样品进行分析。结果表明,两批织纹螺样品中均含有高浓度的河豚毒素及其衍生物,包括三脱氧河豚毒素、脱水河豚毒素和单加氧河豚毒素等,而且两个织纹螺样品中的毒素组成非常相似。因此,导致这两起中毒事件的致毒因子是河豚毒素及其衍生物。江苏和福建两地织纹螺中毒素组成的相似性显示两地织纹螺可能具有相同或相近的毒素来源。
译  名：
Analysis of toxins in snails responsible for two poisoning incidents in China
作  者：
YU Ren-cheng1,ZHOU Ming-jiang1,LI Ai-feng1,2,ZHANG Qing-chun1,WANG Yun-feng1,LI Jun1,YAN Tian1,Michael QUILLIAM3,Bernd LUCKAS4(1.Key Laboratory of Marine Ecology and Environmental Sciences,Institute of Oceanology,Chinese Academy of Sciences,Qingdao,266071,China;2.Department of Environmental Science and Engineering,Ocean University of China,Qingdao,266003,China;3.Institute of Marine Bioscience,National Research Council of Canada,Halifax,B3H3Z1;Canada;4.Institute of Nutrition,Friedrich Schiller-University of Jena,Jena,07743,Germany)
关键词：
Nassarius spp.;tetrodotoxin;paralytic shellfish poisoning;hydrophilic interaction chromatography;liquid chromatography-mass spectrometry
摘  要：
Poisoning incidents caused by eating snails Nassarius spp.have been reported frequently in the last several years in China.Toxins involved in the poisoning incidents were suspected to be paralytic shellfish toxins(PSTs) produced by toxic algal blooms in adjacent sea areas,since the symptoms of the patients closely resembled those caused by PSTs.However,tetrodotoxin was also reported previously in some snail samples.To elucidate the toxins responsible for the poisoning incident,snail samples collected from Fujian Province and Jiangsu Province in 2002 and 2003,respectively,were analyzed with hydrophilic interaction liquid chromatography coupled with mass spectrometry detector(HILIC-MS).High contents of tetrodo-toxin(TTX) and its isomers and derivatives,including 4-epiTTX,trideoxyTTX,anhydroTTX,deoxyTTX,oxoTTX,were detected in snail samples.The TTX contents in the snail samples collected from Fujian Province and Jiangsu Province were 44.6μg/g and 129μg/g,calibrated with TTX standard.It was suggested that TTX and its derivatives,rather than PSTs,were responsible for the two poisoning incidents in Fujian Province and Jiangsu Province.The closely resemblance of toxin profile between the two snail samples from Fujiang Province and Jiangsu Province suggested that they might have similar toxin sources.However,the origin of TTX and its derivatives in the snails still need more detailed investigation and research.

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