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当前位置: 首页 > 文章 > 蝙蝠蛾拟青霉菌丝体对高尿酸血症小鼠的影响 食用菌学报 2018 (1) 53-59
Position: Home > Articles > Effects of Paecilomyces hepiali Mycelia on Hyperuricemia Mice Induced byPotassium Oxonate and Hypoxanthine Acta Edulis Fungi 2018 (1) 53-59

蝙蝠蛾拟青霉菌丝体对高尿酸血症小鼠的影响

作  者：
马诗经;梁慧嘉;焦春伟;张命龙;谢意珍;李崇;杨咏善;陈家明
单  位：
广东省微生物研究所;广东粤微食用菌技术有限公司
关键词：
蝙蝠蛾拟青霉;高尿酸血症;黄嘌呤氧化酶;尿酸盐转运蛋白1
摘  要：
为探讨蝙蝠蛾拟青霉(Paecilomyces hepiali)菌丝体粉(MPPH)对高尿酸血症小鼠的影响,将小鼠随机分为正常组、模型组、别嘌呤醇组(5mg/kg)、低剂量组(MPPH 250mg/kg)、中剂量组(MPPH 500mg/kg)、高剂量组(MPPH 1000mg/kg)和正常MPPH组,分别给药7d后,同时灌胃次黄嘌呤(500mg/kg)和注射氧嗪酸钾(100mg/kg)联合诱导小鼠构建高尿酸血症模型,继续给药7d,测定小鼠的尿酸、肌酐(creatinine,Cr)、血尿素氮(blood urea nitrogen,BUN)含量,以及黄嘌呤氧化酶(xanthine oxidase,XOD)活性和尿酸盐转运蛋白1(urate transporter 1,URAT 1)水平。结果表明:MPPH可显著降低高尿酸血症小鼠血清和肝脏中的尿酸含量(P<0.01),升高尿液中尿酸水平(P<0.01),抑制肝脏中XOD活性和肾脏中URAT 1过度表达,促进尿酸排泄,且不影响小鼠体重增加,对肝脏、肾脏也无损伤。
译  名：
Effects of Paecilomyces hepiali Mycelia on Hyperuricemia Mice Induced byPotassium Oxonate and Hypoxanthine
作  者：
MA Shijing;LIANG Huijia;JIAO Chunwei;ZHANG Minglong;XIE Yizhen;LI Chong;YANG Yongshan;CHEN Jiaming;Guangdong Yuewei Edible Fungi Technology Co.Ltd.;Guangdong Institute of Microbiology,Guangdong Academy of Sciences;
关键词：
Paecilomyces hepiali;;hyperuricemia;;xanthine oxidase;;urate transporter 1
摘  要：
Effects of mycelia powder of Paecilomyces hepiali(MPPH)were studied on hyperuricemia(HUA)mice induced by hypoxanthine(500 mg/kg)and potassium oxonate(100 mg/kg).Different experimental groups were established as the normal group,the model group,the allopurinol group(5 mg/kg),low MPPH dose group(250 mg/kg),medium MPPH dose group(500 mg/kg),high MPPH dose group(1000 mg/kg)and the normal MPPH group.Mice in each group were administered with the corresponding compounds for seven days before induction of hyperuricemia for another seven days in the model group,the allopurinol group and three MPPH groups with different doses.Then mice in each test group were determined for blood uric acid(BUA)level,serum creatinine(Cr)level,blood urea nitrogen(BUN)level,xanthine oxidase(XOD)activity,and urate transporter 1(URAT1)level,respectively.The results showed that the mycelia powder of P.hepiali significantly reduced the uric acid level in serum and liver of HUA mice(P<0.01),inhibited hepatic XOD activity and overexpression of renal URAT1,promoted excretion of uric acid into the urine and at the same time did no harm to liver or kidney.

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