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当前位置: 首页 > 文章 > 老鹳草膏对佐剂性关节炎大鼠血清VEGF和TGF-β1表达的影响 湖北农业科学 2014 (9) 2111-2113
Position: Home > Articles > Effect of Geranium wilfordii Maxim Ointments(GWMO) on Expression of Serum VEGF and TGF-β1 in Rats with Adjuvant Arthritis(AA) Hubei Agricultural Sciences 2014 (9) 2111-2113

老鹳草膏对佐剂性关节炎大鼠血清VEGF和TGF-β1表达的影响

作  者：
万永霞;王汉海;冯道俊
单  位：
山东省高校生物化学与分子生物学重点实验室/潍坊学院生物与农业工程学院
关键词：
佐剂性关节炎;老鹳草(Geranium wilfordii Maxim)膏;细胞因子;甲氨蝶呤
摘  要：
为观察老鹳草(Geranium wilfordii Maxim)膏对佐剂性关节炎(AA)大鼠模型血清细胞因子VEGF、TGF-β1含量的影响,探讨老鹳草对类风湿性关节炎的作用机理,试验将SD大鼠尾根部皮内注射完全弗氏佐剂(CFA)造模,将造模成功的AA大鼠随机分为3组,于第10天开始分别以生理盐水(模型对照组)、老鹳草膏(老鹳草膏组)和MTX(MTX组)处理各试验组,同时设置空白对照组。第45天乙醚麻醉后眼底采血、ELISA法检测血清中VEGF、TGF-β1的浓度。结果表明,与模型对照组和MTX组相比,老鹳草膏可显著降低AA大鼠血清异常升高的VEGF水平,提高血清TGF-β1含量。表明老鹳草可改善大鼠足关节状态,具有免疫调节功能,有助于机体恢复免疫稳定状态。
译  名：
Effect of Geranium wilfordii Maxim Ointments(GWMO) on Expression of Serum VEGF and TGF-β1 in Rats with Adjuvant Arthritis(AA)
作  者：
WAN Yong-xia;WANG Han-hai;FENG Dao-jun;Shandong Key Laboratory of Biochemistry and Molecular Biology in Universities / College of Bio-engineering and Agriculture , Weifang University;
关键词：
adjuvant arthritis(AA);;Geranium wilfordii Maxim Ointments;;cytokine;;methotrexate(MTX)
摘  要：
To investigate the effect of Geranium wilfordii Maxim Ointments(GWMO) on the expression of Serum VEGF、TGF-β1 in the adjuvant arthritis(AA) in rats and to further explore the mechanism of GWMO in the treatment of rheumatoid arthritis(RA),60 SD rats were randomly divided into four groups including Blank control group, Model control group, GWMO group and MTX group. Except of the blank control group, the other three groups were injected CFA at the root of tail for establishing experimental arthritis model and treated with saline, GWMO and Methotrexate(MTX), respectively after modeling 10 days. After five weeks of treatment, the concentrations of VEGF and TGF-β1 in the serum collected from rats' fundus were determined by ELISA. The results showed that GWMO could significantly inhibit the excretion of VEGF in the adjuvant arthritis rats' serum and made it back to normal(compared with Model group P<0.01, compared with MTX group P<0.01), and raise serum TGF-β1 content(compared with Model group P<0.01, compared with MTX group P<0.05). It is indicated that GWMO could improve the ankle state of rats and regulate immune function to help the body restoring immune stability.

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