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当前位置: 首页 > 文章 > 金银花叶黄酮对衰老模型小鼠的体内抗氧化作用 食品科学 2017 (19) 171-176
Position: Home > Articles > In Vivo Antioxidant Activity of Honeysuckle Leaf Flavonoids in Aging Mice FOOD SCIENCE 2017 (19) 171-176

金银花叶黄酮对衰老模型小鼠的体内抗氧化作用

作  者：
罗磊;张冰洁;关宁宁;马丽苹;朱文学
单  位：
河南科技大学食品与生物工程学院河南省农产品干燥装备工程技术研究中心
关键词：
金银花叶;黄酮;衰老模型小鼠;D-半乳糖;抗氧化能力
摘  要：
目的:研究金银花叶黄酮对衰老小鼠体内抗氧化系统的调节作用。方法:采用颈背部皮下注射D-半乳糖法构建衰老小鼠模型,用不同剂量(低、中、高剂量分别为50、100、200 mg/(kg·d))的金银花叶黄酮灌胃小鼠,观察小鼠体质量变化,并计算肝脏、脑、肾脏、脾脏及心脏指数,测定小鼠血清及肝脏、脑、肾脏及心脏组织中总抗氧化能力(total antioxidant capacity,T-AOC)、超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、过氧化氢酶(catalase,CAT)活力及丙二醛(malondialdehyde,MAD)、谷胱甘肽(glutathione,GSH)含量。结果:与空白组相比,模型组小鼠体质量和脏器指数显著下降,血清和各脏器组织中的T-AOC、SOD、GSH-Px、CAT活力及GSH含量均有所降低,MDA含量升高,且大部分差异显著(P<0.05),说明衰老小鼠模型构建成功。与模型组相比,金银花叶黄酮各剂量组小鼠体质量和脏器指数均有所升高,血清和脏器中的T-AOC、SOD、GSH-Px、CAT活力及GSH含量均有不同程度的回升,MDA含量降低,高剂量组效果最显著。结论:金银花叶黄酮能有效提高衰老小鼠的抗氧化能力,其抗氧化机制可能与提高机体抗氧化酶活性和还原性保护物质含量、降低脂质过氧化物含量有关。
译  名：
In Vivo Antioxidant Activity of Honeysuckle Leaf Flavonoids in Aging Mice
作  者：
LUO Lei;ZHANG Bingjie;GUAN Ningning;MA Liping;ZHU Wenxue;Henan Agricultural Products Drying Equipment Engineering Technology Research Center, College of Food and Bioengineering,Henan University of Science and Technology;
关键词：
honeysuckle leaf;;flavonoids;;aging mice;;D-galactose;;antioxidant capacity
摘  要：
Objective: To study the effect of honeysuckle leaf flavonoids on the antioxidant defense system in various tissues of aging mice. Methods: An aging mouse model was established by subcutaneous injection of D-galactose in the neck and back, and the aging mice were gavaged with different doses(50, 100 and 200 mg/(kg·d)) of honeysuckle leaf flavonoids. Changes in body weight were observed over the 30-day administration period, and liver, brain, kidney, spleen and heart indexes and the contents of malondialdehyde(MDA) and glutathione(GSH) and the activities of total antioxidant capacity(T-AOC), superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and catalase(CAT) in the liver, brain, kidney, heart and serum of mice were assessed. Results: Compared with the control group, the body weight and organ indexes of mice in the model group decreased significantly, T-AOC, SOD, GSH-Px and CAT activities and GSH content in the serum and organs decreased, and MDA content increased, with significant differences being observed for most of these parameters(P < 0.05), indicating successful construction of aging mice model. Compared with the model group, body weight, organ indexes and T-AOC, SOD, GSH-Px and CAT activities as well as GSH content in the serum and organ tissues were improved for all dose groups; on the other hand, MDA content was decreased. The most significant effect was obtained at the high dose. Conclusion: Honeysuckle leaf flavonoids can effectively improve the antioxidant defense capacity of aging mice through a mechanism related to the increased activities of antioxidant enzymes and the reduced contents of protective substances and lipid peroxide.

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