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Position: Home > Articles > Protective Effects of Grape Seed Proanthocyanidins against Oxidative Damage in Brain Tissue of Mice FOOD SCIENCE 2009,30 (21) 374-376

葡萄籽原花青素对小鼠脑组织氧化损伤的保护作用

作  者：
刘玉梅;张自强;邓雯;杨雪峰
单  位：
河南科技学院动物科学学院;河南科技大学动物科技学院
关键词：
葡萄籽原花青素;D-半乳糖;脑组织;氧化损伤
摘  要：
目的:探讨葡萄籽原花青素(GSP)对D-半乳糖(D-gal)致小鼠脑组织氧化损伤的影响。方法:采用D-半乳糖制造小鼠脑组织氧化损伤模型。GSP组在造模同时分别灌胃给予小鼠10、20、40mg/kg的GSP,每天1次,6周后观察其对氧化损伤小鼠脑组织总超氧化物歧化酶(T-SOD)、谷胱甘肽过氧化物酶(GSH-PX)活性和丙二醛(MDA)含量的影响,同时在透射电子显微镜下观察小鼠大脑皮质超微结构的变化。结果:GSP对D-gal致小鼠脑组织抗氧化酶活力降低和脂质过氧化物含量升高有显著的抑制作用,并改善了D-gal导致的小鼠大脑皮质超微结构变化。结论:GSP对D-gal致小鼠脑组织氧化损伤具有保护作用。
译  名：
Protective Effects of Grape Seed Proanthocyanidins against Oxidative Damage in Brain Tissue of Mice
作  者：
LIU Yu-mei1,ZHANG Zi-qiang1,DENG Wen1,YANG Xue-feng2 (1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China ; 2. College of Animal Science, Henan Institute of Science and Technology, Xinxiang 453003, China)
关键词：
grape seed proanthocyanidins (GSPs);D-galactose (D-gal);brain tissue;oxidative damage
摘  要：
Kunming male mice ((20 ± 2) g) were used as experimental animals for exploring the protective effects of grape seed proanthocyanidins (GSPs) against oxidative damage in brain tissue of mice. Oxidative brain damage models of mice were established with D-galactose induction. Mice with brain damage were orally administered with GSP at doses of 10, 20 and 40 mg/kg serving as low-, medium- and high-dose groups, respectively or identical doses of normal saline serving as model control group once a day for 6 weeks and normal mice also administered with normal saline served as normal control group. After 6 weeks, all mice were sacrificed and anatomized for assaying the activities of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH- PX), and the content of malondialdehyde (MDA) in brain tissue and observing cerebral cortex ultrastructure under transmission electron microscopy (TEM). Results showed that GSP was able to significantly inhibit the decrease of T-SOD and GSH- PXactivities and the increase of MDA content in brain tissue of mice with oxidative damage induced by D-galactose, and alleviate the ultrastructural pathological changes in cerebral cortex. Therefore, GSP has protective effects against oxidative damage in brain tissue of mice induced by D-galactose.

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