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当前位置: 首页 > 文章 > 乳铁蛋白对卵清白蛋白过敏小鼠外周血中Th1/Th2细胞平衡的影响 食品科学 2012 (21) 308-313
Position: Home > Articles > Effect of Lactoferrin on Th1/Th2 Cell Balance in Peripheral Blood of BALB/C Mice with Food Allergy FOOD SCIENCE 2012 (21) 308-313

乳铁蛋白对卵清白蛋白过敏小鼠外周血中Th1/Th2细胞平衡的影响

作  者：
张浩;胡志和
单  位：
天津市食品生物技术重点实验室天津商业大学生物技术与食品科学学院
关键词：
食物过敏;乳铁蛋白;Th1/Th2细胞平衡;免疫调节
摘  要：
利用卵清白蛋白(OVA)建立BALB/C小鼠食物过敏模型,观察乳铁蛋白(lactoferrin,Lf)对该食物过敏机体的免疫调节作用。小鼠分别接受预防性乳铁蛋白处理和胃肠道刺激期间灌胃乳铁蛋白,最后一次处理1h后检测其外周血中IFN-γ、IL-4、TGF-β、IL-6、IL-10、IL-12p40和IgE的变化。结果表明:2mg/(kg.d)(以体质量计)的Lf在胃肠道刺激期间显著提高了IFN-γ和IL-12p40水平而降低了IL-4和IL-6水平,但20mg/(kg.d)的Lf降低了所有这些细胞因子。同时,Lf明显降低了血清中IgE浓度而提高了IFN-γ/IL-4比值,20mg/(kg.d)的Lf对IgE影响较大,2mg/kg的Lf对IFN-γ/IL-4比值影响较大。此外,预防性处理中的Lf均显著降低了IL-4、IL-6、IL-10、IL-12p40、IFN-γ、TGF-β和IgE水平,并且20mg/(kg.d)的Lf效果较好,且该剂量明显提高了IFN-γ/IL-4比值。因此,Lf能够改善OVA诱导的食物过敏小鼠Th1/Th2细胞的平衡,具有重要的免疫调节作用。
译  名：
Effect of Lactoferrin on Th1/Th2 Cell Balance in Peripheral Blood of BALB/C Mice with Food Allergy
作  者：
ZHANG Hao,HU Zhi-he(Tianjin Key Laboratory of Food and Biotechnology,College of Biotechnology and Food Science, Tianjin University of Commerce,Tianjin 300134,China)
关键词：
food allergy;lactoferrin;Th1/Th2 cell balance;immunoregulatory effect
摘  要：
The aim of this study was to determine the immunoregulatory effect of lactoferrin on Th1/Th2 cell balance in the peripheral blood of mice with food allergy.In order to establish allergic mouse models,BALB/C mice were repeatedly sensitized and challenged with ovalbumin.Lactoferrin was administrated to mice during preventive treatment or intragastric provocation.The levels of serum IgE,IFN-γ,IL-4,IL-6,IL-10,IL-12p40 and TGF-β were determined at 1 h after the last administration.The results showed that Th1/Th2 cell balance in the peripheral blood of mice with food allergy revealed a shift towards Th2 cell direction.Lactoferrin administration at 2 mg/(kg?d) significantly increased IFN-γ and IL-12p40 levels and IFN-γ/IL-4 ratio,but decreased IgE,IL-4 and IL-6 levels during intragastric provocation.When the dosage was increased to 20 mg/(kg?d),these cytokines except IFN-γ/IL-4 ratio were significantly decreased.Meanwhile,lactoferrin administration significantly increased the levels of serum IL-4,IL-6,IL-10,IL-12p40,IFN-γ,TGF-β and IgE during preventive treatment,especially at 20 g/(kg?d),resulting in a significant increase in IFN-γ/IL-4 ratio.Therefore,lactoferrin can promote Th1/Th2 cell balance in ovalbumin-induced food allergy mice.

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