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甲基代谢的生理功能

作  者:
王磊;王良;赵芹
关键词:
甜菜碱;蛋氨酸;胆碱;叶酸;甲基化反应
摘  要:
甲基在体内可以参与肌酸、磷脂酰胆碱、肉碱合成,还可以通过胞嘧啶调控基因表达和组蛋白甲基化.甲基团重甲基化可生成内源性蛋氨酸,甲基团可来源于甲基供体如胆碱、甜菜碱以及再生甲基.甲基团的缺乏会对机体的甲基化反应产生复杂的不良影响.如果日粮中叶酸、甜菜碱、胆碱不足,势必需要更多的蛋氨酸参与体内重要的甲基化反应,而使得用于合成体蛋白质和生长的蛋氨酸比例降低.相反,如果体内的叶酸、甜菜碱等甲基供体过量,就会节省一部分参与甲基代谢的蛋氨酸,从而有利于生长.
作  者:
WANG Lei;WANG Liang;ZHAO Qin;Shandong Sunwin Biotechnology Co., Ltd.;
单  位:
WANG Lei%WANG Liang%ZHAO Qin%Shandong Sunwin Biotechnology Co., Ltd.
关键词:
betaine;;methionine;;choline;;folate;;methylation reactions
摘  要:
Methyl can participate in the synthesis of creatine, phosphatidylcholine and carnitine in vivo, and also regulate gene expression and histone methylation through cytosine. Methyl methylation can produce endogenous methionine, and methyl groups can be derived from methyl donors such as choline, betaine and regenerated methyl.The lack of methyl group has a complex adverse effect on the methylation of the organism. If the folic acid, betaine,and choline in the diet are insufficient, more methionine will be required to participate in the important methylation in the body, and the proportion of methionine used in the synthetic body protein and growth is reduced. Conversely,if the body's folic acid, betaine and other methyl donors overdose, it will save a part of methionine that participates in methyl metabolism, which is beneficial to growth.

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