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Position: Home > Articles > Advances in Ovine Prolificacy Gene BMPR1B Journal of Domestic Animal Ecology 2015,36 (5) 1-6

绵羊多羔主效基因BMPR1B的研究进展

作  者:
潘章源;狄冉;刘秋月;储明星
单  位:
中国农业科学院北京畜牧兽医研究所农业部畜禽遗传资源与种质创新重点实验室
关键词:
BMPR1B基因;FecB;绵羊;多羔
摘  要:
骨形态发生蛋白受体1B(Bone morphogenetic protein receptor 1B,BMPR1B)是一种重要的跨膜受体蛋白,主要参与转化生长因子β(TGF-β)通路,其在调控成骨分化、细胞扩散以及卵巢卵泡发育等过程中起重要作用,并直接影响如绵羊等动物的繁殖性状。绵羊BMPR1B基因发生A746G突变(命名为FecB突变),导致第249位氨基酸由谷氨酰胺(Q)转变为精氨酸(R),进而使得绵羊排卵数和产羔数显著增加,因此BMPR1B成为目前最受关注的绵羊多羔主效基因。论文就绵羊BMPR1B基因定位、功能机制研究进展及其对高繁殖力绵羊的影响进行了综述,同时也对BMPR1B功能研究中一些亟待解决的问题展开了讨论。
译  名:
Advances in Ovine Prolificacy Gene BMPR1B
作  者:
PAN Zhang-yuan;DI Ran;LIU Qiu-yue;CHU Ming-xing;Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture,Institute of Animal Science,Chinese Academy of Agricultural Sciences;
关键词:
BMPR1Bgene;;FecB;;sheep;;prolificacy
摘  要:
Bone morphogenetic protein receptor 1B(BMPR1B)is a transmembrane receptor protein primarily involved in TGF-βpathway and plays an important role in the regulation of osteoblast differentiation,cell proliferation and development of ovarian follicles.The sheep BMPR1 Bgene,when A746Gmutation(FecB)happens,results in one amino acid substitution(arginine to glutamate)increasing the ovulation rate and litter size significantly in ewes.Therefore,BMPR1 Bis one of most important high fecundity major genes.The paper reviewed recent progress in the research on gene mapping,effect on reproduction,functional mechanism of BMPR1 Band discussed on some unresolved issues in the research of BMPR1 Bgene function.

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