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当前位置: 首页 > 文章 > 反溶剂-高压均质法制备羟基喜树碱纳米粒工艺及其性质研究 现代农业科技 2013 (8) 138-139,142
Position: Home > Articles > Preparation and Characterization of Nanoparticle of Hydroxycamptothecin by Anti-solvent High Pressure Homogenization Method Modern Agricultural Science and Technology 2013 (8) 138-139,142

反溶剂-高压均质法制备羟基喜树碱纳米粒工艺及其性质研究

作  者：
孙佰贺;王志超;赵修华;李庆勇
单  位：
东北林业大学林业生物制剂教育部工程研究中心
关键词：
羟基喜树碱;反溶剂法;高压均质;纳米粒
摘  要：
为了减小羟基喜树碱的粒径,该研究首先采用了反溶剂法(以二甲基甲酰胺,三氯甲烷为反溶剂)对羟基喜树碱原粉微粉化,使其粒径降低至1 000 nm以下,再通过高压均质法将羟基喜树碱微粉纳米化.在反溶剂过程中,考察了多种溶剂及反溶剂,确定了以二甲基甲酰胺为溶剂,三氯甲烷为反溶剂;在高压均质过程中,考察了药物浓度、均质压力及均质循环数,最终确定了制备羟基喜树碱纳米粒的最优条件为:药物浓度为0.8 mg/mL,均质压力为60 MPa,均质循环数为20个循环.以上条件制备的羟基喜树碱纳米粒粒径为135.1 nm;通过激光粒度分析仪及X射线衍射(XRD)对羟基喜树碱原粉与纳米粒进行了性质分析,与原粉相比羟基喜树碱纳米粒的粒径及结晶度均有所降低.
译  名：
Preparation and Characterization of Nanoparticle of Hydroxycamptothecin by Anti-solvent High Pressure Homogenization Method
单  位：
State Engineering Laboratory of Bio-Resources Eco-Utilization%Key Laboratory of Forest Plant Ecology,Northeast Forestry University,Ministry of Education%Engineering Research Center of Forest Bio-preparation,Ministry of Education,Northeast Forestry University,Harbin Heilongjiang 150040
关键词：
hydroxycamptothecin%anti-solvent method%high pressure homogenization technique%nanoparticle
摘  要：
To decrease the particle size of hydroxycamptothecin,the nanoparticle of hydroxycamptothecin in an antisolvent process(using dimethylformamide as solvent and chloroform as atsolvent)and a high pressure homogenization technique was studied in the research.In antisolvent process,we inspected multiple solvents and antisolvents,then chose dimethylformamide and chloroform.In the high pressure homogenization process,drug concentration,pressure and the number of cycles were investigated.And we prepared the nano hydroxycamptothecin with the particle size of 135.1 nm under the optimal condition(drug concentration 0.8 mg/mL,60 MPa and 20 cycles).To detect the characterization of raw hydroxycamptothecin and nano hydroxycamptothecin,we adopted laser particle analyzer and differential scanning calorimetry(DSC).The particle size and crystallinity of nano hydroxycamptothecin decreased greatly compared with raw hydroxycamptothecin.

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