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当前位置: 首页 > 文章 > QuEChERS/液相色谱串联质谱法测定水产品中氯硝柳胺 食品工业科技 2016,37 (23) 316-318+323
Position: Home > Articles > Simultaneous determination of niclosamide in aquatic products by QuEChERS / liquid chromatography-tandem mass spectrometry Science and Technology of Food Industry 2016,37 (23) 316-318+323

QuEChERS/液相色谱串联质谱法测定水产品中氯硝柳胺

作  者：
刘伶俐;万译文;伍远安;索纹纹;肖维
单  位：
农业部渔业产品质量监督检验测试中心(长沙)湖南省水产科学研究所;农业部渔业产品质量监督检验测试中心;湖南省水产科学研究所
关键词：
氯硝柳胺;Qu ECh ERS;液相色谱-质谱/质谱法;水产品
摘  要：
本文建立了Qu ECh ERS/液相色谱-质谱/质谱(HPLC-MS/MS)测定水产品中氯硝柳胺残留量的分析方法。样品经氨化乙腈提取,C_18吸附剂与中性氧化铝净化后,采用HPLC-MS/MS选择反应监测(SRM)负离子模式测定进行定性、定量分析。结果表明:在0.5~100 ng/m L范围内,峰面积与浓度线性良好,相关系数为0.9996;氯硝柳胺检出限(LOD)为0.2μg/kg,定量限(LOQ)为0.4μg/kg,检测结果的相对标准偏差为4.33%~9.91%(n=5),平均加标回收率达到74.6%~92.1%。该方法具有较高的适用性和选择性,在水产品中氯硝柳胺的残留测定中具有很好的应用前景。
译  名：
Simultaneous determination of niclosamide in aquatic products by QuEChERS / liquid chromatography-tandem mass spectrometry
作  者：
LIU Ling-li;WAN Yi-wen;WU Yuan-an;SUO Wen-wen;XIAO Wei;Fishery Products Quality Supervision and Testing Center,Ministry of Agriculture;Hunan Fisheries Science Institute;Collaborative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province;
关键词：
niclosamide;;QuEChERS;;liquid chromatography-mass spectrometry/mass spectrometry;;aquatic products
摘  要：
To establish an analytical method for the determination of niclosamide in aquatic products by QuEChERS / liquid chromatography-tandem mass spectrometry,the sample was extracted with acetonitril,the extract was cleaned up with C_18 and Alumina-N,the mass spectrometer was operated in the negative ion mode using selected reaction monitoring for the qualitative and quantitative analysis. The linear ranges were from 0.5 to100 ng / m L with a good linear relationship( R~2= 0.9996).The detection limits of this method for niclosamide residues were 0.2 μg / kg,and the limits of quantification were 0.4 μg / kg.The relative standard deviations ranging from 4.33%~9.91%( n = 5) and the average recovery rates were from74.6% ~ 92.1%. The method proposed by this paper possessed higher applicability and selectivity. It is promising in real applications of determining the niclosamide residues in aquatic products.

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