中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 连翘酯苷脂质体在雏鸡体内的药动学研究 中国畜牧兽医 2014,41 (2) 153-158
Position: Home > Articles > Study on Pharmacokinetics of Forsythiaside Liposome in Chicks China Animal Husbandry & Veterinary Medicine 2014,41 (2) 153-158

连翘酯苷脂质体在雏鸡体内的药动学研究

作  者：
赵海焦;徐卫康;贾志华;孙玉成;侯晓林;陆彦;吴国娟;张中文
单  位：
黑龙江省宝泉岭农场机关;北京农学院动物科学技术学院
关键词：
连翘酯苷;脂质体;药动学;高效液相色谱法
摘  要：
试验旨在考察连翘酯苷脂质体静脉给药后在雏鸡体内的药物动力学和组织分布。将连翘酯苷脂质体与连翘酯苷水溶液分别以20mg/kg体重剂量给雏鸡静脉注射,于不同时间点取心脏、肝脏、脾脏、肺脏、肾脏组织和血液。HPLC法测定各时间点血液及各组织中连翘酯苷浓度。连翘酯苷脂质体和连翘酯苷溶液的血药浓度—时间曲线均符合二室开放模型,药动学参数消除半衰期(t1/2β)分别为(1.79±0.050)和(0.11±0.006)h,药时曲线下面积(AUC)分别为(39.95±2.32)和(4.26±0.39)(μg·h)/mL,体清除率(CLs)分别为(0.56±0.04)和(4.73±0.41)mg/(h·kg),连翘酯苷脂质体给药后在肝脏、脾脏、肺脏中的分布较连翘酯苷水溶液有明显提高。连翘酯苷脂质体明显改变了连翘酯苷的药动学行为,与游离药物相比,其有效延长了药物作用时间,在网状内皮系统丰富的组织有靶向性聚集作用。
译  名：
Study on Pharmacokinetics of Forsythiaside Liposome in Chicks
作  者：
ZHAO Hai-jiao;XU Wei-kang;JIA Zhi-hua;SUN Yu-cheng;HOU Xiao-lin;LU Yan;WU Guo-juan;ZHANG Zhong-wen;Department of Animal Science and Technology,Beijing University of Agriculture;Heilongjiang Baoquanling Farm Authority;
关键词：
forsythiaside;;liposome;;pharmacokinetics;;high performance liquid chromatography
摘  要：
The study was aimed to evaluate the pharmacokinetics and tissue distribution of forsythiaside liposome in chicks by intravenous administration.The pharmacokinetics of chicks with intravenous administration of forsythiaside liposome and forsythiaside solution 20mg/kg was studied and the concentrations of forsythiaside in heart,liver,spleen,lung,kidney and plasma were determined by HPLC.The plasma concentration-time curves of forsythiaside liposome and forsythiaside solution were both fit to the two-compartment model and the pharmacokinetic parameters were(1.79±0.050)and(0.11±0.006)h for t1/2β,(39.95±2.32)and(4.26±0.39)(μg·h)/mL for AUC,(0.56±0.04)and(4.73±0.41)mg/(h·kg)for CLs.Compared with the liposome to the solution,the drug distribution in liver,spleen and lung were obviously elevated.Compared with forsythiaside solution,the forsythiaside liposome could significantly prolong the resident time of forsythiaside in the blood circulating system and could be concentrated at the target tissue rich in the reticuloendothelial system.

相似文章

导出引用
计量
文章访问数: 2
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46