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p53基因及其在家禽肿瘤性疾病应用研究进展

作  者:
张会霞;张桂华;张慧;牛玉娟;孙芹芹;李悦;刘思当
单  位:
山东农业大学动物科技学院
关键词:
p53;突变体;肿瘤
摘  要:
抑癌基因p53作为一种转录因子,通过调控其靶基因在应激反应中启动的不同生物学过程,包括细胞凋亡、细胞周期阻滞或衰老等,发挥其在肿瘤抑制中的作用.近年人类医学对p53基因进行研究的较多,但是动物医学文献中有关p53基因的研究报道相对较少.论文就国内外对p53基因及其编码产物的结构、作用机制、应用、检测等方面的研究进展以及在禽病中的表达和应用进行综述,为家禽肿瘤性疾病的诊治提供参考.
作  者:
ZHANG Hui-xia;ZHANG Gui-hua;ZHANG Hui;NIU Yu-juan;Sun Qin-qin;LI Yue;LIU Si-dang;Animal Science and Veterinary Medicine,Shandong Agricultural University College;
关键词:
p53;;mutant;;tumor
摘  要:
Tumor-suppressor p53 plays a key role in tumor prevention.As a transcription factor,p53 transcriptionally regulates its target genes to initiate different biological processes in response to stress,including apoptosis,cell cycle arrest or senescence,to exert its function in tumor suppression.The study of p53 gene has become a hot topic in medical molecular biology research in recent years,and it is also the tumor suppressor gene with the highest incidence rate of human tumor.However,the research progress of p53 in veterinary field is relatively slow.This paper briefly reviewed the research progress in the structure,mechanism,application and detection of p53 gene and its encoded products at home and abroad.The new research direction of p53 in poultry tumour infectious diseases is prospected,which provides a new idea for the diagnosis and treatment of tumor diseases in poultry.

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