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Position: Home > Articles > Research on Interaction and Diseases between p53 and TGF-β in Regulation of Cell Growth China Animal Husbandry & Veterinary Medicine 2012,39 (4) 81-84

p53和TGF-β在细胞生长调控中的相互作用及其与疾病的研究进展

作  者:
郑艳生;郑世民;高雪丽
单  位:
东北农业大学动物医学学院
关键词:
p53;TGF-β;细胞生长调控
摘  要:
肿瘤抑制因子p53是第一个被发现的肿瘤抑制因子蛋白家族成员,该蛋白家族能感知许多细胞信号以调节细胞增殖、凋亡和分化。TGF-β是机体内重要的生理生化调节因子,在机体细胞生长分化、胚胎发育、创伤修复等方面发挥重要作用。p53与TGF-β信号转导密切相关。作者对近年p53与其依赖的TGF-β在细胞生长调控方面的相互联系研究进展作一简要综述。
译  名:
Research on Interaction and Diseases between p53 and TGF-β in Regulation of Cell Growth
作  者:
ZHENG Yan-sheng,ZHENG Shi-min,GAO Xue-li(College of Animal Medicine,Northeast Agricultural University,Harbin 150030,China)
关键词:
p53;TGF-β;cell growth regulation
摘  要:
p53 is the first discovered member of tumor suppression protein family,which can sense many cell signals to regulate cell proliferation,apoptosis and differentiation.TGF-β is a important physiological and biochemical regulator in organism which plays a important role in cell growth,differentiation,embryonic development,damage repair and so on.p53 has a close relationship with TGF-β signaling pathway.The relationship of p53 and TGF-β in cell growth regulation in latest years were reviewed.

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